Dialyzers Outperform Activated Charcoal Filters for Extracorporeal Cisplatin Removal in an Isolated Perfused Porcine Liver Model.

IF 2.5 4区医学 Q2 SURGERY

European Surgical Research Pub Date : 2026-10-13 DOI:10.1159/esr/actag006

Birte Ohm, Kenji Fukushima, Pascal Paschenda, Zoltan Czigany, Jens Bertram, Thomas Kraus, Fabian Kiessling, Yonson Ku, Takumi Fukumoto, René H Tolba

{"title":"Dialyzers Outperform Activated Charcoal Filters for Extracorporeal Cisplatin Removal in an Isolated Perfused Porcine Liver Model.","authors":"Birte Ohm, Kenji Fukushima, Pascal Paschenda, Zoltan Czigany, Jens Bertram, Thomas Kraus, Fabian Kiessling, Yonson Ku, Takumi Fukumoto, René H Tolba","doi":"10.1159/esr/actag006","DOIUrl":null,"url":null,"abstract":"Introduction: Percutaneous isolated hepatic perfusion enables regional delivery of high-dose chemotherapy while limiting systemic exposure through extracorporeal drug removal. In current clinical practice, this is achieved by the use of activated charcoal-based filtration systems, which are limited by finite adsorption capacity and non-selective binding. Hemodialysis filters may provide a membrane-based alternative for extracorporeal drug elimination. This study compared the efficacy of both systems for cisplatin removal.Methods: An isolated perfused porcine liver model was used. Livers were randomized into charcoal filtration, hemodialysis filtration, or control groups (n=5 per group). Cisplatin was administered into the hepatic circulation, and drug removal was performed according to group allocation. Cisplatin concentrations, liver injury markers, bile production, and blood cell counts were assessed.Results: Hemodialysis filters achieved significantly greater cisplatin clearance compared with activated charcoal filters, with sustained differences over time. Liver injury markers and bile production did not differ between groups. Blood cell counts revealed no relevant treatment effects.Conclusion: Hemodialysis filters improve cisplatin removal without affecting liver injury markers or blood cell counts in this experimental model.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"1"},"PeriodicalIF":2.5000,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Surgical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/esr/actag006","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Percutaneous isolated hepatic perfusion enables regional delivery of high-dose chemotherapy while limiting systemic exposure through extracorporeal drug removal. In current clinical practice, this is achieved by the use of activated charcoal-based filtration systems, which are limited by finite adsorption capacity and non-selective binding. Hemodialysis filters may provide a membrane-based alternative for extracorporeal drug elimination. This study compared the efficacy of both systems for cisplatin removal.

Methods: An isolated perfused porcine liver model was used. Livers were randomized into charcoal filtration, hemodialysis filtration, or control groups (n=5 per group). Cisplatin was administered into the hepatic circulation, and drug removal was performed according to group allocation. Cisplatin concentrations, liver injury markers, bile production, and blood cell counts were assessed.

Results: Hemodialysis filters achieved significantly greater cisplatin clearance compared with activated charcoal filters, with sustained differences over time. Liver injury markers and bile production did not differ between groups. Blood cell counts revealed no relevant treatment effects.

Conclusion: Hemodialysis filters improve cisplatin removal without affecting liver injury markers or blood cell counts in this experimental model.

查看原文本刊更多论文

在离体灌注猪肝模型中，透析器优于活性炭过滤器用于体外顺铂去除。

导读：经皮离体肝脏灌注可以实现高剂量化疗的局部递送，同时通过体外药物去除限制全身暴露。在目前的临床实践中，这是通过使用活性炭基过滤系统来实现的，活性炭基过滤系统受有限的吸附能力和非选择性结合的限制。血液透析过滤器可以为体外药物消除提供一种基于膜的替代方案。本研究比较了两种系统去除顺铂的疗效。方法：采用离体猪肝灌注模型。肝脏随机分为炭滤组、血液透析滤组和对照组（每组n=5）。顺铂进入肝循环，按分组进行脱药。评估顺铂浓度、肝损伤标志物、胆汁生成和血细胞计数。结果：与活性炭过滤器相比，血液透析过滤器获得了更大的顺铂清除率，并随着时间的推移持续存在差异。肝损伤标志物和胆汁生成在两组间无差异。血细胞计数显示没有相关的治疗效果。结论：血液透析滤器在不影响肝损伤标志物和血细胞计数的情况下，促进顺铂清除。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Surgical Research 医学-外科

CiteScore

2.30

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： ''European Surgical Research'' features original clinical and experimental papers, condensed reviews of new knowledge relevant to surgical research, and short technical notes serving the information needs of investigators in various fields of operative medicine. Coverage includes surgery, surgical pathophysiology, drug usage, and new surgical techniques. Special consideration is given to information on the use of animal models, physiological and biological methods as well as biophysical measuring and recording systems. The journal is of particular value for workers interested in pathophysiologic concepts, new techniques and in how these can be introduced into clinical work or applied when critical decisions are made concerning the use of new procedures or drugs.