Case of Bundibugyo Virus Disease in Goma, Democratic Republic of the Congo with Lack of Transmission to Breastfeeding Infant.

IF 1.9 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Felicien M Maisha, Kahatwa K Serge, Kambale Kasonia, Zebedée Luhavo Kakule, Jayakrishnan Ajayakumar, John A Lednicky, Andrew J Curtis, J Glenn Morris
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Abstract

Disease due to Bundibugyo virus (BDBV), an Orthoebolavirus species, reemerged in April 2026, in Ituri Province, Democratic Republic of the Congo. A 35-year-old woman transported the body of a possible BDBV-infected patient from Bunia in Ituri Province to Goma for burial; she was accompanied by an 8-month-old breastfeeding child. Six days after arrival in Goma, she noted onset of fever and malaise and was empirically started on therapy for malaria; 4 days later she developed bloody diarrhea and a bloody vaginal discharge and was started on metronidazole for possible amebic dysentery. When her condition worsened she was admitted to hospital in Goma, where a blood sample was positive by real-time polymerase chain reaction (RT-PCR) test for BDBV, with a second positive test on hospital day 7. By day 14 of hospitalization fever and major symptoms had resolved and repeat RT-PCR tests × 2 were negative. Her child did not show evidence of infection, and no family members or health care workers at HEAL Africa Hospital developed illness.

刚果民主共和国戈马市本迪布焦病毒病病例,缺乏对哺乳婴儿的传播。
本迪布焦病毒(一种正埃博拉病毒)引起的疾病于2026年4月在刚果民主共和国伊图里省再次出现。一名35岁妇女将一名可能感染bdbv的患者的尸体从伊图里省布尼亚运送到戈马埋葬;她身边有一个正在哺乳的8个月大的孩子。抵达戈马6天后,她注意到开始发烧和不适,并开始经验性地接受疟疾治疗;4天后,她出现带血腹泻和带血阴道分泌物,并开始服用甲硝唑治疗可能的阿米巴痢疾。当她的病情恶化时,她被送往戈马的一家医院,通过实时聚合酶链反应(RT-PCR)检测,血液样本呈BDBV阳性,并在住院第7天进行了第二次阳性检测。入院第14天发热和主要症状消退,重复RT-PCR × 2检测均为阴性。她的孩子没有显示出感染的迹象,也没有家庭成员或非洲治愈医院的卫生保健工作者患病。
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来源期刊
American Journal of Tropical Medicine and Hygiene
American Journal of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.20
自引率
3.00%
发文量
508
审稿时长
3 months
期刊介绍: The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine. The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development. The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal. Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries
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