Topical application of urolithin A activates mitophagy and enhances mitochondrial function to promote skin longevity.

IF 4.5 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2026-09-30 eCollection Date: 2026-10-16 DOI:10.1016/j.isci.2026.117646

Davide D'Amico, Julie Faitg, Frédéric Amaral, Carine Ballihaut, Andréane M Fouassier, Charlotte Tissot, Isha Rana, Julien Laboureau, Natascha Hennighausen, Marianne Brandt, Nicholas Kron, Xavier Marat, Chantal Jouy, Annie F Black, Gayané Azadiguian, Delphine Guillon, Jean-Thierry Simonnet, Chris Rinsch, Anurag Singh

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引用次数: 0

Abstract

Urolithin A (UA, Mitopure), a postbiotic that promotes mitophagy and mitochondrial function following oral administration, was evaluated for its effects on skin health in human skin models and when applied topically to healthy subjects in randomized clinical studies. UA tested in 2D and 3D reconstructed human skin and ex vivo human skin explants showed enhanced mitochondrial respiration, activated mitophagy markers, reduced inflammatory mediators and senescence-associated markers, and increased proteins involved in extracellular matrix structure and epidermal differentiation. Safety was confirmed in a human repeat-insult patch test. In randomized, placebo-controlled clinical studies, UA reduced periorbital wrinkle depth after 8 weeks and attenuated UVB-induced erythema. Skin transcriptomics supported increased extracellular matrix and epidermal development programs together with decreased inflammatory and senescence-associated signaling. These findings indicate that topical UA engages cellular pathways associated with skin resilience to promote skin health and longevity.

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局部应用尿素A激活线粒体自噬，增强线粒体功能，促进皮肤长寿。

尿素A （UA, Mitopure）是一种在口服后促进线粒体自噬和线粒体功能的后生物，在人体皮肤模型中评估了其对皮肤健康的影响，并在随机临床研究中局部应用于健康受试者。在2D和3D重建的人体皮肤和离体人体皮肤外植体中测试的UA显示，线粒体呼吸增强，线粒体自噬标记物激活，炎症介质和衰老相关标记物减少，参与细胞外基质结构和表皮分化的蛋白质增加。安全性在人体重复损伤斑贴试验中得到证实。在随机、安慰剂对照的临床研究中，UA减少了8周后的眶周皱纹深度，并减轻了uvb诱导的红斑。皮肤转录组学支持细胞外基质和表皮发育程序的增加，以及炎症和衰老相关信号的减少。这些发现表明，局部UA参与与皮肤弹性相关的细胞通路，促进皮肤健康和长寿。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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