Consensus recommendations for neurofibromatosis type 1 management in Asia Pacific.

IF 4.5 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2026-10-01 eCollection Date: 2026-10-16 DOI:10.1016/j.isci.2026.117002

Yemima Berman, Beom Hee Lee, Anthony Pak-Yin Liu, Yoshihiro Nishida, Ee Shien Tan, Zhichao Wang

引用次数: 0

Abstract

Neurofibromatosis type 1 (NF1) is a complex multisystem disorder requiring coordinated multidisciplinary care. This study aimed to develop consensus recommendations for NF1 management in the Asia-Pacific region. A modified Delphi process involving two survey rounds and a virtual meeting was conducted with experts from nine countries. A total of 141 statements were evaluated using a 9-point Likert scale with a 75% consensus threshold. Consensus was achieved across key domains including diagnosis, genetic testing, surveillance, and management. Experts emphasized the importance of multidisciplinary care, risk-adapted surveillance, and integration of genetic counseling and imaging in clinical practice. These findings provide regionally relevant guidance to support consistent and practical NF1 management across diverse healthcare systems.

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亚太地区1型神经纤维瘤病治疗的共识建议。

1型神经纤维瘤病（NF1）是一种复杂的多系统疾病，需要协调的多学科治疗。本研究旨在为亚太地区NF1管理提出共识建议。经过修改的德尔菲程序涉及两轮调查和与来自9个国家的专家进行的虚拟会议。共有141个陈述使用9分李克特量表和75%的共识阈值进行评估。在诊断、基因检测、监测和管理等关键领域达成了共识。专家们强调了临床实践中多学科护理、风险适应性监测以及遗传咨询和影像学整合的重要性。这些发现提供了与区域相关的指导，以支持在不同的医疗保健系统中一致和实用的NF1管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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