Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

IF 3.5 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2026-10-13 DOI:10.1002/cmdc.70506

Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart

引用次数: 0

Abstract

This review provides an overview of recent advances in the development of multitarget drugs (MTDs) for cardiac diseases, with a particular focus on emerging molecular scaffolds and their pharmacological properties. We discuss the fundamental principles of cardiac polypharmacology and multitarget drug design, highlighting key compound classes, such as 1,4-benzothiazepines, 1,4-dihydropyridines (DHPs), and polyphenol derivatives. Particular emphasis is placed on the relationship between the structural features and the pharmacological activity, efficacy, and therapeutic potential of these compounds.

查看原文本刊更多论文

心血管疾病的多靶点药物设计：化学与医学的桥梁。

本文综述了治疗心脏病的多靶点药物（MTDs）的最新进展，重点介绍了新兴的分子支架及其药理特性。我们讨论了心脏多药理学和多靶点药物设计的基本原理，重点介绍了关键化合物类别，如1,4-苯并噻唑类，1,4-二氢吡啶（DHPs）和多酚衍生物。特别强调的是结构特征与这些化合物的药理活性、功效和治疗潜力之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.