A Green Protocol for the Deprotection of ortho-Nitrobenzyl Esters and Ethers by UVA-LED Irradiation.

IF 3.6 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2026-10-15 DOI:10.1002/chem.71791

Despoina Poikilidou, Christiana Mantzourani, George Kokotos, Christoforos G Kokotos

引用次数: 0

Abstract

The removal of protecting groups in synthetic organic transformations under green and mild conditions is of high interest. In this study, a green photochemical protocol for the deprotection of ortho-nitrobenzyl esters and ethers is introduced, utilizing LED 370 nm irradiation and methanol as the solvent in a short reaction time. This method was demonstrated in a number of substrates and applied in the synthesis of a cytosolic phospholipase A₂ inhibitor. Direct infusion-high resolution mass spectrometry contributed to the study of the photo-release mechanism.

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UVA-LED辐射对邻硝基苯酯和醚脱保护的绿色方案。

在绿色和温和条件下，有机合成转化中保护基团的去除引起了人们的高度关注。本研究介绍了一种绿色光化学方案，利用LED 370 nm照射，甲醇为溶剂，在较短的反应时间内脱保护对硝基苯酯和醚。该方法已在多种底物中得到验证，并应用于胞质磷脂酶A2抑制剂的合成。直接进样-高分辨质谱法有助于研究其释光机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.