Decarboxylative functionalization with redox-active esters in a single-electron transfer manner

IF 9.8 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Science China Chemistry Pub Date : 2026-07-27 DOI:10.1007/s11426-026-3403-4

Siyu Xia, Zhongxuan Cai, Shengyu Zhuang, Jin Xie

引用次数: 0

Abstract

In recent years, we have witnessed the emergence of efficient and practical radical-involving reactions enabled by N-(acyloxy)phthalimide (NHPI) esters as redox-active intermediates. The preparation of carboxylic acids as redox-active esters (RAEs) has emerged as a powerful strategy to overcome the inherent limitations of direct decarboxylative functionalization. This review summarizes the recent advances in decarboxylative transformations of RAEs initiated by single-electron transfer (SET) under photoredox, electrochemical, and thermally driven catalytic conditions. These new activation modes have enabled diverse formation of C–C and C–X (X = B, N, O, F, Si, P, S, Ge) bonds, including decarboxylative alkylation, alkenylation, alkynylation, arylation, acylation, and heteroatom functionalization.

查看原文本刊更多论文

以单电子转移方式用氧化还原活性酯进行脱羧功能化

近年来，我们已经见证了N-（酰基）邻苯二胺（NHPI）酯作为氧化还原活性中间体的有效和实用的自由基参与反应的出现。羧酸作为氧化还原活性酯（RAEs）的制备已成为克服直接脱羧功能化固有局限性的有力策略。本文综述了近年来在光氧化还原、电化学和热驱动催化条件下，由单电子转移（SET）引发的RAEs脱羧转化的研究进展。这些新的激活模式使得C-C和C-X （X = B、N、O、F、Si、P、S、Ge）键的形成多样化，包括脱羧烷基化、烯化、烷基化、芳化、酰化和杂原子功能化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.