Advances in photocatalytic deracemization reactions

IF 9.8 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Science China Chemistry Pub Date : 2026-09-01 DOI:10.1007/s11426-026-3489-2

Yi Tang, Cheng Li, Chunhui Zhang, Shao-Hua Xiang, Junmin Zhang, Bin Tan

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Abstract

Direct deracemization of racemates presents an ideal access to acquire highly enantioenriched molecules. Research in photocatalytic deracemization, since its first demonstration in 2018, has been advancing steadily and witnessed explosive growth in 2025, becoming a more diverse and active field. This review comprehensively summarizes recent advances in photocatalytic deracemization by categorizing the catalytic systems employed, including organocatalysis, metal catalysis, biocatalysis, or cooperative strategies, with a focus on their evolution and mechanisms. The diversification of catalytic systems has advanced the understanding of photochemical stereocontrol and offered useful guidance for the development of novel catalysts and the optimization of reaction systems. Moreover, these advances have laid a solid foundation for the preparation of valuable chiral compounds, enabling their broader application in pharmaceutical development and materials science.

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光催化脱羧反应的研究进展

外消旋体的直接去消旋是获得高度富集对映体分子的理想途径。自2018年首次示范以来，光催化脱羧研究稳步推进，并在2025年出现爆发式增长，成为一个更加多样化和活跃的领域。本文综述了近年来光催化脱羧的研究进展，对所采用的催化体系进行了分类，包括有机催化、金属催化、生物催化和协同催化，并重点介绍了它们的演变和机制。催化体系的多样化促进了人们对光化学立体控制的认识，为开发新型催化剂和优化反应体系提供了有益的指导。此外，这些进展为制备有价值的手性化合物奠定了坚实的基础，使其在药物开发和材料科学中得到更广泛的应用。

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来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.