On the Discovery of Glomerular Capillary Hypertension: A Homage to Barry M. Brenner, MD

Abstract

Glomerular capillary hypertension plays a key role in the pathophysiologic response to kidney injury, including glomerulonephritis, diabetes mellitus, and congenital or acquired nephron loss. The discovery of this phenomenon was a transforming period in the history of nephrology. This essay describes this event and how it impacted the field, with an emphasis on the seminal contributions of Barry M. Brenner and his colleagues.

Glomerular capillary hypertension plays a key role in the pathophysiologic response to kidney injury, including glomerulonephritis, diabetes mellitus, and congenital or acquired nephron loss. The discovery of this phenomenon was a transforming period in the history of nephrology. This essay describes this event and how it impacted the field, with an emphasis on the seminal contributions of Barry M. Brenner and his colleagues.