A Nickel Pre-Catalyst for the O-Arylation of Primary, Secondary, and Tertiary Alcohols with (Hetero)aryl Chlorides

IF 2.4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Organometallics Pub Date : 2026-10-12 Epub Date: 2026-09-25 DOI:10.1021/acs.organomet.6c00313

Emily C. Jackson, Erika M. H. Elliott, Kathleen M. Morrison, Peter L. Fox, Katherine N. Robertson, Patrick L. DeRoy, Mark Stradiotto

引用次数: 0

Abstract

While base metal-catalyzed cross-couplings of alcohols and (hetero)aryl chlorides have emerged over the past decade, the development of a single pre-catalyst capable of promoting such transformations spanning all of primary, secondary, and tertiary (aliphatic) alcohols remains an enduring challenge. Herein we disclose the easily prepared, air-stable 4-cyanophenyl pre-catalyst (L2)Ni(4-CN-Ph)Cl (L2 = CgPhen-DalPhos), which is shown to be capable of promoting, with useful reaction scope, the C–O cross-coupling of all such alcohol classes with (hetero)aryl chlorides.

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一种镍预催化剂用于伯、仲、叔醇与（杂）芳酰氯的o -芳化反应

虽然在过去的十年中，贱金属催化的醇和（杂）芳酰氯的交叉偶联已经出现，但开发一种能够促进所有伯、仲、叔（脂肪族）醇的这种转化的单一预催化剂仍然是一个持久的挑战。在此，我们公开了易于制备的空气稳定的4-氰苯基预催化剂（L2）Ni(4-CN-Ph)Cl (L2 = CgPhen-DalPhos)，它被证明能够在有用的反应范围内促进所有这些醇类与（杂）芳酰氯的C-O交叉偶联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organometallics 化学-无机化学与核化学

CiteScore

5.60

自引率

7.10%

发文量

382

审稿时长

1.7 months

期刊介绍： Organometallics is the flagship journal of organometallic chemistry and records progress in one of the most active fields of science, bridging organic and inorganic chemistry. The journal publishes Articles, Communications, Reviews, and Tutorials (instructional overviews) that depict research on the synthesis, structure, bonding, chemical reactivity, and reaction mechanisms for a variety of applications, including catalyst design and catalytic processes; main-group, transition-metal, and lanthanide and actinide metal chemistry; synthetic aspects of polymer science and materials science; and bioorganometallic chemistry.