Substrate Promiscuity of CHST1 Enables Efficient Synthesis of Galactose-6-O-Sulfated Glycans for Siglec Recognition Profiling

IF 17.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2026-10-15 DOI:10.1002/anie.4139901

Shumin Bao,Tangliang Shen,MohammadHossein Shabahang,Shuquan Fan,Hongshuai Lv,Guitao Bai,Jun Pan,Lei Li

引用次数: 0

Abstract

Extreme substrate promiscuity of human CHST1 was revealed toward β-galactosides and β-GalNAc glycosides, which enabled modular synthesis of a large library of sulfated and non-sulfated glycans. Glycan microarray assays using these glycans revealed disparate modulatory effects of galactose-6-O-sulfation toward multiple Siglecs.

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CHST1的底物乱交性使半乳糖-6- o -硫酸甘聚糖的有效合成用于Siglec识别谱分析

揭示了人CHST1对β-半乳糖苷和β-GalNAc苷的极端底物混杂性，这使得模块化合成了大量的硫酸和非硫酸聚糖库。使用这些聚糖的聚糖微阵列分析揭示了半乳糖-6- o -硫酸化对多种Siglecs的不同调节作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.