Ashutosh Khaswal, Hadi Mahmodi, Ellie Mok, Thomas R Cox, Irina Kabakova
{"title":"Multiscale mechanical analysis of live breast cancer spheroids by micro-compression and Brillouin imaging.","authors":"Ashutosh Khaswal, Hadi Mahmodi, Ellie Mok, Thomas R Cox, Irina Kabakova","doi":"10.1111/jmi.70185","DOIUrl":null,"url":null,"abstract":"<p><p>Recent developments in cancer mechanobiology have highlighted the importance of tumour mechanics as a potential marker of disease progression. Three-dimensional tumour models provide simplified yet physiological relevance exhibiting mechanical heterogeneity. However, comprehensively capturing both bulk and localised biomechanical properties remains challenging. In this study, triple negative breast cancer live spheroids were assessed through non-invasive Brillouin microscopy as well as micro-compression testing which provide maps of microscale mechanical heterogeneity and bulk-scale mechanical assessment, respectively. Together, these approaches form a multi-scale mechanical framework that may improve the interpretation of disease-related mechanical changes and support cancer treatment discovery.</p>","PeriodicalId":16484,"journal":{"name":"Journal of microscopy","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of microscopy","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1111/jmi.70185","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MICROSCOPY","Score":null,"Total":0}
引用次数: 0
Abstract
Recent developments in cancer mechanobiology have highlighted the importance of tumour mechanics as a potential marker of disease progression. Three-dimensional tumour models provide simplified yet physiological relevance exhibiting mechanical heterogeneity. However, comprehensively capturing both bulk and localised biomechanical properties remains challenging. In this study, triple negative breast cancer live spheroids were assessed through non-invasive Brillouin microscopy as well as micro-compression testing which provide maps of microscale mechanical heterogeneity and bulk-scale mechanical assessment, respectively. Together, these approaches form a multi-scale mechanical framework that may improve the interpretation of disease-related mechanical changes and support cancer treatment discovery.
期刊介绍：
The Journal of Microscopy is the oldest journal dedicated to the science of microscopy and the only peer-reviewed publication of the Royal Microscopical Society. It publishes papers that report on the very latest developments in microscopy such as advances in microscopy techniques or novel areas of application. The Journal does not seek to publish routine applications of microscopy or specimen preparation even though the submission may otherwise have a high scientific merit.
The scope covers research in the physical and biological sciences and covers imaging methods using light, electrons, X-rays and other radiations as well as atomic force and near field techniques. Interdisciplinary research is welcome. Papers pertaining to microscopy are also welcomed on optical theory, spectroscopy, novel specimen preparation and manipulation methods and image recording, processing and analysis including dynamic analysis of living specimens.
Publication types include full papers, hot topic fast tracked communications and review articles. Authors considering submitting a review article should contact the editorial office first.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
