Analysis of the evolving disease burden of female infertility and its associated risk factors.

IF 2.8 3区医学 Q2 GENETICS & HEREDITY

Journal of Assisted Reproduction and Genetics Pub Date : 2026-10-12 DOI:10.1007/s10815-026-04048-0

Yanchao Lin, Ya Lin

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引用次数: 0

Abstract

Background: The global burden of female infertility is increasing, yet the roles of metabolic syndrome (MetS) and circadian syndrome (CircS) remain poorly understood. This study aimed to describe the global disease burden of female infertility and examine the associations between MetS, CircS, and infertility.

Methods: Global Burden of Disease (GBD) 2023 data were used to assess trends in infertility prevalence. Cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) were used to evaluate associations between metabolic status and infertility using weighted logistic regression.

Results: The global number of women with infertility nearly doubled from 59.8 million in 1990 to 114.5 million in 2023 (ASR, + 25.27%), with the sharpest increase in Western Sub-Saharan Africa (247.6%). Both MetS (OR = 1.41, 95% CI 1.00-1.99) and CircS (OR = 1.46, 95% CI 1.04-2.07) were associated with an elevated risk of infertility. The combined presence of MetS and CircS was also positively associated with infertility (OR = 1.51, 95% CI 1.04-2.18). Among women under 35 years of age, CircS (OR = 1.69; 95% CI 1.00-2.87) and the combination of both syndromes (OR = 1.77; 95% CI 1.02-3.10) were associated with an elevated risk of infertility. Elevated blood pressure was the individual component most strongly associated with infertility.

Conclusions: The global burden of female infertility is substantial. Both MetS and CircS are significant risk factors for infertility, with a stronger association for CircS among younger women. Elevated blood pressure showed the strongest association among the individual metabolic components. These findings support integrating metabolic and circadian risk assessment into infertility prevention strategies.

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女性不孕症疾病负担演变及其相关危险因素分析。

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.