{"title":"What determines skin wound regeneration or scar healing?","authors":"Zhan Su, Ruonan Lu, Xuanfen Zhang","doi":"10.1016/j.molmed.2026.09.012","DOIUrl":null,"url":null,"abstract":"<p><p>Skin wound regeneration, scar healing, or scar evolution is a spatiotemporally continuous process with mechanisms that remain unclear. Dynamic interactions between repair cells, including fibroblasts, and the surrounding extracellular matrix scaffold are key determinants. Skin wound models that gradually deepen from the epidermis allow the simultaneous investigation of regeneration and scar-healing processes and their regulation.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":18.1000,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in molecular medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.molmed.2026.09.012","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Skin wound regeneration, scar healing, or scar evolution is a spatiotemporally continuous process with mechanisms that remain unclear. Dynamic interactions between repair cells, including fibroblasts, and the surrounding extracellular matrix scaffold are key determinants. Skin wound models that gradually deepen from the epidermis allow the simultaneous investigation of regeneration and scar-healing processes and their regulation.
期刊介绍:
Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.