Cytotoxicity and α-Amylase Inhibitory Activities of Limonoids From the Leaves of Azadirachta indica.

IF 2.9 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2026-10-01 DOI:10.1002/cbdv.71835

Ying Yang, Yu-Xin Yan, Ming-Hua Qiu

引用次数: 0

Abstract

Three new limonoids, azadiraindins H-J (1-3), together with three known analogues, were isolated from the leaves of Azadirachta indica. The structures of these compounds were elucidated by comprehensive spectroscopic analysis, including IR, MS, HR-ESI-MS, 1D NMR, and 2D NMR. In addition, all compounds exhibited cytotoxic activities in vitro against HL-60, A-549, MCF-7, and SW480 cell lines, with IC₅₀ values ranging from 7.51 to 21.97 µM. Notably, compound 2 demonstrated significant cytotoxicity.

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印楝叶柠檬素的细胞毒性及α-淀粉酶抑制活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.