Effects of dual-task training on health-related quality of life and cognitive function in people with Parkinson's disease: a systematic review and meta-analysis.
Leandro Cerda-Pérez, Catalina Gutiérrez-Rojas, Valentina Retamal-Salazar, Karina Rodríguez-Faúndez, Javiera Venegas-Alarcón, Jordan Hernandez-Martinez, Cristian Sandoval-Vásquez, Pablo Valdés-Badilla, Edgar Vásquez-Carrasco
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引用次数: 0
Abstract
Introduction: Dual-task training is proposed as a rehabilitative strategy to mitigate motor and cognitive impairments in patients with Parkinson's disease (PD). This systematic review and meta-analysis sought to consolidate existing information regarding the impact of dual-task therapies on health-related quality of life (HRQoL) and cognitive performance in middle-aged and older persons diagnosed with PD.
Methods: A systematic review of randomized controlled trials (RCTs) published to May 2026 was performed utilizing PubMed, EBSCOhost, Scopus, and Web of Science. The chosen studies adhered to the PICOS framework. The Methodological quality and certainty of evidence were assessed using the Cochrane Risk of Bias 2 tool and GRADE framework, respectively. The review protocol is recorded in PROSPERO under the number CRD420251159680.
Results: Out of 3,037 identified records, 10 RCTs met the eligibility criteria and were included in the systematic review, of which 9 contributed data to the meta-analysis. The meta-analysis showed a statistically significant but modest effect on HRQoL measured with the Parkinson's Disease Questionnaire-39 (SMD = 0.35; 95% CI: 0.03-0.67; p = 0.03). No significant between-group effects were observed for TMT-A (MD = 0.99; 95% CI: -3.38 to 5.37; p = 0.66), TMT-B (SMD = 0.02; 95% CI: -0.24 to 0.29; p = 0.86), or MoCA (SMD = 0.19; 95% CI: -0.26 to 0.64; p = 0.41).
Conclusion: Dual-task interventions may produce a modest improvement in HRQoL in people with Parkinson's disease, whereas the current evidence does not demonstrate significant benefits for the cognitive outcomes assessed. These findings should be interpreted cautiously given the limited number of studies, methodological limitations, and clinical heterogeneity across interventions.
期刊介绍：
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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