Vascular brain injury modifies the relationship between sleep duration, cognition, and white matter hyperintensity burden in the Alzheimer's disease continuum.

IF 12.8 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2026-10-01 DOI:10.1002/alz.71838

Soraya Lahlou, Zahinoor Ismail, Eric E Smith, Thien Thanh Dang-Vu, AmanPreet Badhwar

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引用次数: 0

Abstract

Introduction: Self-reported sleep duration is associated with dementia-risk and vascular brain injury markers, including white matter hyperintensities (WMHs), yet how additional cerebrovascular pathology alters these relationships remains unclear.

Method: In a deeply phenotyped cohort (735) including healthy and Alzheimer's disease (AD) continuum individuals (subjective and mild cognitive impairment [MCI], dementia [AD], MCI and AD with high vascular burden [+V]), sleep was assessed using the Pittsburgh Sleep Quality Index. Individuals were classified as WMH-only or WMH+ (WMHs with microbleeds, infarcts, or cerebral amyloid angiopathy). Linear models tested interactions between sleep duration, WMH+ status, and diagnostic group on WMH burden and cognition.

Results: In MCI+V and AD, WMH+ significantly amplified the association between shorter sleep and greater WMH burden. In AD, longer sleep related to better cognition in WMH+ but worse cognition in WMH-only (exploratory).

Discussion: Additional vascular brain injury modifies how sleep relates to WMH burden and cognition across the AD continuum, highlighting the importance of moving beyond WMHs alone.

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血管性脑损伤改变了阿尔茨海默病连续体中睡眠时间、认知和白质高强度负担之间的关系。

自我报告的睡眠时间与痴呆风险和血管性脑损伤标志物（包括白质高强度（WMHs））相关，但其他脑血管病理如何改变这些关系尚不清楚。方法：在一个深度表型队列（735）中，包括健康和阿尔茨海默病（AD）连续个体（主观和轻度认知障碍[MCI]，痴呆[AD]， MCI和AD伴高血管负担[+V]），使用匹兹堡睡眠质量指数评估睡眠。个体被分为单纯WMH或WMH+（伴有微出血、梗死或脑淀粉样血管病的WMH）。线性模型检验了睡眠时间、WMH+状态和诊断组对WMH负担和认知的相互作用。结果：在MCI+V和AD中，WMH+显著放大了睡眠时间缩短与WMH负担加重之间的关联。在AD中，睡眠时间越长，WMH+组认知能力越好，而WMH-only组认知能力越差（探索性）。讨论：额外的血管性脑损伤改变了睡眠与AD连续体中WMH负担和认知的关系，强调了超越WMH的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.