Visible-light driven macrocyclization of peptides: from a vinyl to an α-selenoketone motif.

IF 2.8 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2026-10-28 DOI:10.1039/d6ob01411a

Mateusz Waliczek, Zuzanna Słomiana, Klaudia Faba, Martyna Strączek, Piotr Stefanowicz

引用次数: 0

Abstract

We report a visible-light-driven, chemoselective macrocyclization of peptides that converts linear vinyl precursors into cyclic products bearing an α-selenoketone motif. The transformation proceeds in aqueous medium under mild conditions using a substoichiometric photocatalyst and blue LED irradiation, delivering high yields (>90%). The method is operationally simple, green, and broadly applicable to peptide macrocyclization.

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可见光驱动的多肽大环化：从乙烯基到α-硒酮基序。

我们报道了一种可见光驱动的、化学选择性的多肽大环化，将线性乙烯基前体转化为带有α-硒酮基序的环状产物。在温和的条件下，在水介质中使用亚化学计量光催化剂和蓝色LED照射进行转化，产率高（>90%）。该方法操作简单，绿色环保，广泛适用于多肽大环化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.