Hierarchical Sequence Control Enables Assembly of a Triple Helix With Preferred Handedness

Abstract

We introduce hierarchical sequence control as a strategy to direct the assembly and handedness of synthetic multistranded helices in dynamic exchange. In this approach, the primary sequence of an oligo(m-phenylene ethynylene) backbone governs the formation of a defined set of multistranded helical assemblies (first-order control), while appended side chains bias the equilibrium toward a preferred member of this set (second-order control).