Systemic RVX-208 Attenuates Experimental Periodontitis Through Inflammatory Host Modulation.

IF 5.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontal research Pub Date : 2026-10-10 DOI:10.1111/jre.70183

Sheikh Alam, Simrah Ansari, Birtan T Yilmaz, David J Cohen, James Sugai, Caroline Carrico, Melissa Morgan, Matthew S Halquist, Sinem Esra Sahingur, Barbara D Boyan, Zvi Schwartz, William V Giannobile, Zhao Lin

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引用次数: 0

Abstract

Aims: This study investigated whether systemic treatment of RVX-208, a selective BET protein inhibitor, could ameliorate experimental periodontitis in a prophylactic setting and examined transcriptomic changes associated with RVX-208 in vitro.

Methods: Porphyromonas gingivalis (Pg) lipopolysaccharide (LPS) was injected into gingiva in mice twice a week for 6 weeks to induce periodontitis. RVX-208 or vehicle was administered via oral gavage every Monday-Friday, beginning 1 week before LPS injection and continuing for 7 weeks. The periodontal bone loss and osteoclastic activity were evaluated through micro-CT and histological analyses. THP-1 human monocytic cells were treated with Pg bacteria, with or without RVX-208 and JQ1, and RNA-sequencing was performed.

Results: Pg LPS delivery led to periodontal bone loss in mice. Compared with vehicle, systemic treatment of RVX-208 reduced alveolar bone loss and the number of tartrate-resistant acid phosphatase (TRAP) positive cells. In vitro, RVX-208 suppressed the expression of a set of inflammatory genes in THP-1 cells and led to a more moderate and limited effect on transcriptome compared to pan-BET inhibitor JQ1.

Conclusion: Systemic RVX-208 treatment reduced periodontal bone loss in a prophylactic setting in this experimental periodontitis model. In THP-1 cells, RVX-208 suppresses the global inflammatory response induced by Pg.

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系统性RVX-208通过炎症宿主调节减轻实验性牙周炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of periodontal research 医学-牙科与口腔外科

CiteScore

6.90

自引率

5.70%

发文量

103

审稿时长

6-12 weeks

期刊介绍： The Journal of Periodontal Research is an international research periodical the purpose of which is to publish original clinical and basic investigations and review articles concerned with every aspect of periodontology and related sciences. Brief communications (1-3 journal pages) are also accepted and a special effort is made to ensure their rapid publication. Reports of scientific meetings in periodontology and related fields are also published. One volume of six issues is published annually.