Goals and challenges for senescence research

IF 22.7 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2026-10-09 DOI:10.1038/s41556-026-02076-7

Cleo L. Bishop, Feyza Engin, Jing-Dong Jackie Han, Valery Krizhanovsky, Guang-Hui Liu, Ana O’Loghlen, João F. Passos, Zhongjun Zhou

引用次数: 0

Abstract

The basis and physiological functions of senescence have been challenging to establish as senescent states encompass varying hallmarks in disease and ageing, and too little is known about which cells undergo senescence in which contexts. In this Viewpoint, we asked leading researchers in the field to discuss what upcoming questions can help us deepen our knowledge of senescence and what challenges lie ahead.

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衰老研究的目标与挑战。

衰老的基础和生理功能一直具有挑战性，因为衰老状态包括疾病和衰老的不同特征，而且对哪些细胞在哪些环境下经历衰老知之甚少。在这个观点中，我们邀请了该领域的主要研究人员讨论哪些即将到来的问题可以帮助我们加深对衰老的认识，以及未来的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology