Urolithiasis in Pediatric Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (ALL/LLy): A Single-Center Case Series of Clinical, Metabolic, and Imaging Features.
Burak Yuzuguldu, Marissa Krieger, Julie Comella-Higgins, Ahmad Mohamed, Ezekiel Young, Meghan Higman, Matthew Barth, Kara M Kelly
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引用次数: 0
Abstract
Background: Urolithiasis is an underrecognized complication in pediatric acute lymphoblastic leukemia/lymphoma (ALL/LLy), often associated with glucocorticoid therapy.
Observations: We report 4 cases of urolithiasis occurring at different diagnostic and treatment phases, 3 requiring intervention. Presenting symptoms included flank pain, hematuria, and urinary discomfort. In 1 case, renal abnormalities were incidentally identified on PET/CT performed for remission assessment.
Conclusions: Urolithiasis may occur across ALL/LLy diagnosis and treatment, particularly after glucocorticoid exposure and in patients with additional risk factors. Early recognition in patients with unexplained abdominal or urinary symptoms is essential to prevent complications.
期刊介绍：
Journal of Pediatric Hematology/Oncology (JPHO) reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. The journal publishes original research, commentaries, historical insights, and clinical and laboratory observations.
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