Chromosome crowding shapes spindle geometry

IF 22.7 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2026-10-09 DOI:10.1038/s41556-026-02021-8

Jing Xie, Daniele Fachinetti

引用次数: 0

Abstract

Accurate chromosome segregation requires precise spindle organization, but how spindle architecture adapts to genome size remains unclear. A study now highlights a general scaling law based on chromosome crowding that shapes spindle architecture, with broad implications for evolution and disease.

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染色体拥挤形成纺锤体几何形状。

准确的染色体分离需要精确的纺锤体组织，但纺锤体结构如何适应基因组大小仍不清楚。现在，一项研究强调了基于染色体拥挤形成纺锤体结构的一般标度定律，这对进化和疾病具有广泛的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology