Informant Presence Fails to Enhance Alzheimer's Diagnosis in Complex Veteran Cases.

IF 2.5 4区医学 Q3 CLINICAL NEUROLOGY

Dementia and Geriatric Cognitive Disorders Pub Date : 2026-10-09 DOI:10.1159/dem/aciag009

Maureen K O Apos Connor, Brandon Frank, Hannah H Noah, Samantha K Harrington, Emily E Metcalf, Renee DeCaro, Ana Vives-Rodriguez, Brenna Hagan, Samantha Atlas, Landon Hurley, Katherine W Turk, Andrew E Budson

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引用次数: 0

Abstract

Introduction: Informant reports are thought helpful for Alzheimer's disease (AD) diagnosis. We hypothesized that informants would improve diagnostic accuracy, operationalized as agreement between clinical impression and amyloid PET (aPET) findings.

Methods: This study was a retrospective analysis of 168 Veterans referred for aPET due to diagnostic uncertainty or atypical presentation (Mage=69.3, SD=5.8). We examined the association between diagnostic accuracy and presence of an informant, patient's MoCA score, and informant type.

Results: We found no evidence that informant presence was associated with diagnostic accuracy (OR = 0.92, 95% CI 0.48, 1.72), that this association varied by patient cognitive status as measured by MoCA (interaction OR = 1.13, 95% CI 0.97, 1.33), or that diagnostic accuracy differed by informant type (spouse/partner: OR = 1.23, 95% CI 0.55, 2.79; other: OR = 0.91, 95% CI 0.29, 2.71).

Conclusion: Our findings suggest informant presence does not necessarily enhance diagnostic accuracy for complex AD presentations. This highlights the continued value of aPET imaging in complex clinical presentations.

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在复杂的退伍军人病例中，信息提供者的存在不能提高阿尔茨海默病的诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dementia and Geriatric Cognitive Disorders 医学-精神病学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： As a unique forum devoted exclusively to the study of cognitive dysfunction, ''Dementia and Geriatric Cognitive Disorders'' concentrates on Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field.