{"title":"Novel understanding in diagnosis and management of exercise-induced bronchoconstriction.","authors":"John W Dickinson","doi":"10.1080/1744666X.2026.2747863","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Exercise-induced bronchoconstriction (EIB) is a common cause of exercise-related respiratory symptoms in athletes and is traditionally diagnosed by demonstrating airway narrowing following exercise or surrogate bronchoprovocation testing. Whilst this provides objective evidence of bronchoconstriction, it offers limited insight into the underlying pathophysiology of airway dysfunction.</p><p><strong>Areas covered: </strong>This review discusses emerging developments in EIB, focusing on biomarkers of airway inflammation and injury, respiratory oscillometry, breathing pattern assessment and wearable respiratory monitoring. The concept that EIB may represent the clinical manifestation of a broader process of airway injury and remodeling is also considered. Relevant literature was identified through searches of PubMed and Google Scholar with no lower date restriction to May 2026, supplemented by reference-list searching.</p><p><strong>Expert opinion: </strong>The future challenge in EIB is no longer simply confirming bronchoconstriction but identifying athletes at risk of airway dysfunction before clinically significant disease develops. Emerging biomarkers, oscillometry and continuous respiratory monitoring may enable earlier phenotyping and more personalized management than conventional bronchoprovocation testing alone. Collectively, these approaches have the potential to shift EIB care from diagnosing established disease toward preserving airway health within a holistic model of athlete respiratory care.</p>","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-11"},"PeriodicalIF":4.0000,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Clinical Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1744666X.2026.2747863","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Exercise-induced bronchoconstriction (EIB) is a common cause of exercise-related respiratory symptoms in athletes and is traditionally diagnosed by demonstrating airway narrowing following exercise or surrogate bronchoprovocation testing. Whilst this provides objective evidence of bronchoconstriction, it offers limited insight into the underlying pathophysiology of airway dysfunction.
Areas covered: This review discusses emerging developments in EIB, focusing on biomarkers of airway inflammation and injury, respiratory oscillometry, breathing pattern assessment and wearable respiratory monitoring. The concept that EIB may represent the clinical manifestation of a broader process of airway injury and remodeling is also considered. Relevant literature was identified through searches of PubMed and Google Scholar with no lower date restriction to May 2026, supplemented by reference-list searching.
Expert opinion: The future challenge in EIB is no longer simply confirming bronchoconstriction but identifying athletes at risk of airway dysfunction before clinically significant disease develops. Emerging biomarkers, oscillometry and continuous respiratory monitoring may enable earlier phenotyping and more personalized management than conventional bronchoprovocation testing alone. Collectively, these approaches have the potential to shift EIB care from diagnosing established disease toward preserving airway health within a holistic model of athlete respiratory care.
期刊介绍:
Expert Review of Clinical Immunology (ISSN 1744-666X) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology. Members of the International Editorial Advisory Panel of Expert Review of Clinical Immunology are the forefront of their area of expertise. This panel works with our dedicated editorial team to identify the most important and topical review themes and the corresponding expert(s) most appropriate to provide commentary and analysis. All articles are subject to rigorous peer-review, and the finished reviews provide an essential contribution to decision-making in clinical immunology.
Articles focus on the following key areas:
• Therapeutic overviews of specific immunologic disorders highlighting optimal therapy and prospects for new medicines
• Performance and benefits of newly approved therapeutic agents
• New diagnostic approaches
• Screening and patient stratification
• Pharmacoeconomic studies
• New therapeutic indications for existing therapies
• Adverse effects, occurrence and reduction
• Prospects for medicines in late-stage trials approaching regulatory approval
• Novel treatment strategies
• Epidemiological studies
• Commentary and comparison of treatment guidelines
Topics include infection and immunity, inflammation, host defense mechanisms, congenital and acquired immunodeficiencies, anaphylaxis and allergy, systemic immune diseases, organ-specific inflammatory diseases, transplantation immunology, endocrinology and diabetes, cancer immunology, neuroimmunology and hematological diseases.