Mitoses counting in phyllodes tumours: rationale for a standardized hotspot-based approach.

IF 3.8 2区医学 Q2 CELL BIOLOGY

Histopathology Pub Date : 2026-10-08 DOI:10.1111/his.70293

Edward Hadi, Mihir Gudi, Xiaoxian Li, Sandra O'Toole, Ales Ryska, Gary Tse, Sunil Lakhani, Stuart Schnitt, Ian Ellis, Emad Rakha, Puay Hoon Tan

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引用次数: 0

Abstract

Background: Breast phyllodes tumours (PTs) are rare biphasic fibroepithelial neoplasms, classified into benign, borderline and malignant categories. Stromal mitotic activity is a key criterion in grading PT, but the methodology for mitotic assessment has not been clearly articulated.

Materials and methods: We discuss the approach to determining stromal mitotic activity in PTs. Whether the most mitotically active area (hotspot) or an average count across several tumour regions should be adopted is reviewed. We also outline the operational protocol for mitotic hotspot evaluation, accounting for different microscope models with varying field diameters.

Results: A standardized method of determining stromal mitoses in PTs is recommended in order to improve interobserver reproducibility and accuracy in grading PTs. The application of digital tools in stromal mitotic counting is also addressed.

Conclusion: We advocate using the hotspot method of obtaining the highest stromal mitotic count, together with other histological parameters, to classify PTs.

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来源期刊

Histopathology 医学-病理学

CiteScore

10.20

自引率

4.70%

发文量

239

审稿时长

1 months

期刊介绍： Histopathology is an international journal intended to be of practical value to surgical and diagnostic histopathologists, and to investigators of human disease who employ histopathological methods. Our primary purpose is to publish advances in pathology, in particular those applicable to clinical practice and contributing to the better understanding of human disease.