Synthesis, Biological Properties, and Docking Study of 5-Substituted 2-[2-(Aryl)vinyl]-6-methylpyrimidin-4(3H)-ones

IF 1 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2026-09-30 DOI:10.1134/S107036322660219X

Zaruhi A. Hovasyan, Anna G. Sukiasyan, Hasmik A. Sargsyan, Jemma L. Barseghyan, Arthur A. Hambardzumyan, Mark Yu. Danghyan, Astghik A. Shahkhatuni, Arthur A. Harutyunyan

引用次数: 0

Abstract

5-Substituted 6-methyl-2-[(E)-2-aryl)ethenyl]pyrimidin-4(3H)-ones and 2,4-dioxo-6-[(E)-2-arylethenyl]-1,2,3,4-tetrahydropyrimidine-5-carbaldehydes were obtained by condensation of 5-substituted 2,6-dimethylpyrimidin-4(3H)-ones and 6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde with aromatic aldehydes, respectively. The antibacterial and antifungal properties of the obtained compounds were studied and a docking study was carried out against four targets.

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5-取代2-[2-（芳基）乙烯基]-6-甲基嘧啶-4(3H)-酮的合成、生物学性质及对接研究

由5-取代2,6-二甲基嘧啶-4(3H)- 1和6-甲基- 2,3,4-二氧基-6-[(E)-2-芳烯基]-1,2,3,4-甲基-2,4-二氧基-1,2,3,4-四氢嘧啶-5-乙醛与芳香醛分别缩合得到5-取代6-甲基-2-[(E)-2-芳烯基]-1,2,3,4-四氢嘧啶-5-乙醛。研究了所得化合物的抗菌和抗真菌性能，并对四个靶点进行了对接研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.