A hydrated HA/F127 biointerface for polyphenol release modulation and active–passive antibacterial protection on EGCG-loaded UHMWPE joint materials

IF 15.5 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Advanced Composites and Hybrid Materials Pub Date : 2026-09-05 Epub Date: 2026-09-29 DOI:10.1007/s42114-026-02059-0

Yu Han, Jiang-Yu Li, Shu-Min Pan, Peiqi Yu, Mengfan Jing, Yaming Wang, Yue Ren, Ke Tian, Chuntai Liu, Changyu Shen

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引用次数: 0

Abstract

Periprosthetic joint infection remains a major challenge for artificial joint materials, highlighting the need for antibacterial and anti-adhesive ultrahigh molecular weight polyethylene (UHMWPE) surfaces. Here, a hydrated hyaluronic acid (HA)/Pluronic F127 biointerface was constructed on epigallocatechin gallate (EGCG)-loaded UHMWPE to couple polyphenol release modulation with active–passive antibacterial protection. The HA/F127 layer contributed to enhancing the outward migration of EGCG from the UHMWPE matrix. Compared with uncoated EGCG/UHMWPE, this hydrated interface increased the 24 h cumulative EGCG release by 52%, with micro-FTIR depth profiling revealing surface-biased residual EGCG redistribution rather than broad matrix depletion. This release-modulating interface enhanced antibacterial activity, achieving inhibition ratios of 95% against Staphylococcus aureus and 91% against Escherichia coli. By reducing protein adsorption and bacterial retention, the hydrated HA/F127 surface further provided passive anti-adhesive protection complementary to EGCG-mediated bacterial inhibition. The modified surface maintained good cytocompatibility and exhibited a short-term boundary-lubrication effect. Overall, this work presents an active-release/passive-antifouling biointerface strategy to address infection-related challenges of UHMWPE-based biomaterials.

Graphical abstract

A hydrated HA/F127 biointerface was constructed on EGCG-loaded UHMWPE through stepwise interfacial immobilization. The polymeric interface modulates EGCG release while reducing bacterial/protein adhesion, thereby coupling EGCG-mediated active antibacterial activity with passive anti-adhesion and boundary lubrication for infection-resistant UHMWPE joint materials.

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水合HA/F127生物界面对egcg负载UHMWPE连接材料多酚释放调节及主-被动抗菌保护的研究

人工关节周围感染仍然是人工关节材料面临的主要挑战，这突出了对抗菌和抗粘合超高分子量聚乙烯（UHMWPE）表面的需求。本研究在表没食子儿茶素没食子酸酯（EGCG）负载的UHMWPE上构建了水合透明质酸(HA)/Pluronic F127生物界面，将多酚释放调节与主-被动抗菌保护结合起来。HA/F127层有助于增强EGCG从UHMWPE基质向外迁移。与未涂覆的EGCG/UHMWPE相比，这种水化界面使EGCG的24小时累积释放量增加了52%，微红外深度谱图显示的是表面偏置的残余EGCG重新分配，而不是广泛的基质耗尽。该释放调节界面增强了抗菌活性，对金黄色葡萄球菌的抑制率为95%，对大肠杆菌的抑制率为91%。通过减少蛋白质吸附和细菌滞留，水合HA/F127表面进一步提供被动抗粘附保护，补充了egcg介导的细菌抑制作用。改性后的表面保持了良好的细胞相容性，并表现出短期的边界润滑作用。总的来说，这项工作提出了一种主动释放/被动防污的生物界面策略，以解决基于uhmwpe的生物材料与感染相关的挑战。通过逐步界面固定化的方法，在负载鸡蛋cg的超高分子量聚乙烯上构建了水合HA/F127生物界面。聚合物界面调节EGCG的释放，同时减少细菌/蛋白质的粘附，从而将EGCG介导的活性抗菌活性与抗感染UHMWPE关节材料的被动抗粘附和边界润滑结合起来。

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来源期刊

Advanced Composites and Hybrid Materials Multiple-

CiteScore

26.00

自引率

21.40%

发文量

185

期刊介绍： Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.