Longitudinal associations of rapid eye movement (REM) sleep and slow‐wave sleep with plasma Alzheimer's disease biomarkers

IF 12.8 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2026-10-09 DOI:10.1002/alz.71910

Jeongyeon Hwang, Luisa F. Figueredo, Daphne I. Valencia, Thomas M. Tolbert, Eriko Hamada, Li Zhou, Joshua L. Gills, Joaquin Ruiz, Katarina R. Martillo, Sarah S. Chu, Ankita Kumar, Esther M. Blessing, Omonigho M. Bubu, Ankit Parekh, Korey Kam, Anna E. Mullins, David M. Rapoport, Indu Ayappa, Ricardo S. Osorio, Andrew W. Varga

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引用次数: 0

Abstract

INTRODUCTION Data on how sleep architecture relates to progression of plasma Alzheimer's disease biomarkers remains limited. METHODS Sixty‐four cognitively unimpaired older adults (ages 55–90) underwent plasma collection twice 2.6 years apart and polysomnography proximate to the first plasma collection. Plasma amyloid beta (Aβ) 42 and 40 were measured via mass spectrometry. RESULTS Frontal slow‐wave activity (SWA) was inversely associated with plasma Aβ42/40 at cross‐section in bivariate analysis and in a covariate‐adjusted model. In comparison, low rapid eye movement (REM) sleep percentage was associated with a large longitudinal decline in annualized blood‐based Aβ42/40. In exploratory analyses, the association between low REM sleep percentage and faster decline in Aβ42/40 ratio was stronger in the amyloid‐positive group. DISCUSSION In cognitively unimpaired older adults, non‐REM SWA correlates with cross‐sectional amyloid load, whereas REM sleep may predict accelerated amyloid accumulation in preclinical stage, suggesting both may serve as early biomarkers and modifiable interventional targets.

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快速眼动（REM）睡眠和慢波睡眠与血浆阿尔茨海默病生物标志物的纵向关联

关于睡眠结构如何与血浆阿尔茨海默病生物标志物进展相关的数据仍然有限。方法64名认知功能正常的老年人（55-90岁）接受两次血浆采集，间隔2.6年，并在第一次血浆采集前后进行多导睡眠描记术。质谱法测定血浆β淀粉样蛋白42和40。结果：在双变量分析和协变量调整模型中，额叶慢波活动（SWA）与血浆a β42/40在横截面呈负相关。相比之下，低快速眼动（REM）睡眠百分比与年化血液a β42/40的大幅纵向下降有关。在探索性分析中，在淀粉样蛋白阳性组中，低快速眼动睡眠百分比与Aβ42/40比值的快速下降之间的相关性更强。在认知功能未受损的老年人中，非快速眼动睡眠SWA与横截面淀粉样蛋白负荷相关，而快速眼动睡眠可以预测临床前阶段淀粉样蛋白积累的加速，这表明两者都可以作为早期生物标志物和可修改的干预靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.