{"title":"Impact of Strabismus Surgery on Anterior Segment Hemodynamics: An SS AS-OCTA-Based Study.","authors":"Longxiang Huang, Lanbing An, Weidong Zheng","doi":"10.1167/tvst.15.10.7","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to evaluate anterior segment (AS) hemodynamic changes after horizontal rectus muscle surgery using swept-source AS optical coherence tomography angiography (SS AS-OCTA).</p><p><strong>Methods: </strong>This prospective observational study included 99 patients undergoing unilateral horizontal rectus muscle surgery, classified into unilateral recession (UR) and recession-resection (RR) groups. Iris and conjunctival perfusion area (PA), microvascular density (MVD), and vascular density (VD) were measured preoperatively and at postoperative day 1, week 1, and month 1.</p><p><strong>Results: </strong>Iris changes were mild and localized after UR, whereas RR induced broader and transient increases in iris VD and other hemodynamic parameters, most evident at 1 day and 1 week and approaching baseline by 1 month. Conjunctival changes were more pronounced, particularly in operated quadrants, where PA and VD increased early after surgery. Non-operated quadrants also showed increased vascular parameters, suggesting possible redistribution of detectable vascular signals. Higher preoperative iris VD was associated with smaller postoperative changes. No clinically apparent anterior segment ischemia (ASI) was observed during follow-up.</p><p><strong>Conclusions: </strong>Horizontal rectus muscle surgery induces distinct but largely transient AS hemodynamic alterations, with greater changes after RR than UR. SS AS-OCTA enables noninvasive quantitative assessment of perioperative changes in AS vascular signals.</p><p><strong>Translational relevance: </strong>SS AS-OCTA may be most useful for studying reoperations, multiple-muscle or transposition procedures, and patients at increased risk of AS ischemia.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 10","pages":"7"},"PeriodicalIF":2.7000,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657135/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Vision Science & Technology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1167/tvst.15.10.7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
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Abstract
Purpose: The purpose of this study was to evaluate anterior segment (AS) hemodynamic changes after horizontal rectus muscle surgery using swept-source AS optical coherence tomography angiography (SS AS-OCTA).
Methods: This prospective observational study included 99 patients undergoing unilateral horizontal rectus muscle surgery, classified into unilateral recession (UR) and recession-resection (RR) groups. Iris and conjunctival perfusion area (PA), microvascular density (MVD), and vascular density (VD) were measured preoperatively and at postoperative day 1, week 1, and month 1.
Results: Iris changes were mild and localized after UR, whereas RR induced broader and transient increases in iris VD and other hemodynamic parameters, most evident at 1 day and 1 week and approaching baseline by 1 month. Conjunctival changes were more pronounced, particularly in operated quadrants, where PA and VD increased early after surgery. Non-operated quadrants also showed increased vascular parameters, suggesting possible redistribution of detectable vascular signals. Higher preoperative iris VD was associated with smaller postoperative changes. No clinically apparent anterior segment ischemia (ASI) was observed during follow-up.
Conclusions: Horizontal rectus muscle surgery induces distinct but largely transient AS hemodynamic alterations, with greater changes after RR than UR. SS AS-OCTA enables noninvasive quantitative assessment of perioperative changes in AS vascular signals.
Translational relevance: SS AS-OCTA may be most useful for studying reoperations, multiple-muscle or transposition procedures, and patients at increased risk of AS ischemia.
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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