More than just adipose. The impact of GLP1Ra on lean tissue.

IF 5.4 2区生物学 Q2 CELL BIOLOGY

American journal of physiology. Cell physiology Pub Date : 2026-10-06 DOI:10.1152/ajpcell.90062.2026

Maxime Julien, Stewart Jeromson, David C Wright

引用次数: 0

Abstract

Glucagon-like peptide 1 receptor agonists (GLP1Ra) are widely used for the management of obesity and cardiometabolic disease. While causing robust weight loss, GLP1Ra also result in reductions in lean tissue, including skeletal muscle and bone. The purpose of the current review is to discuss key findings demonstrating the effects of GLP1Ra treatment on skeletal muscle and bone, approaches that have been implemented to mitigate these changes, and to highlight important areas of future research.

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不仅仅是脂肪。GLP1Ra对瘦肉组织的影响。

胰高血糖素样肽1受体激动剂（GLP1Ra）广泛用于肥胖和心脏代谢疾病的治疗。在显著减轻体重的同时，GLP1Ra也会导致瘦组织的减少，包括骨骼肌和骨骼。当前综述的目的是讨论证明GLP1Ra治疗对骨骼肌和骨骼的影响的关键发现，已经实施的减轻这些变化的方法，并强调未来研究的重要领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of physiology. Cell physiology 生物-生理学

CiteScore

9.10

自引率

1.80%

发文量

252

审稿时长

1 months

期刊介绍： The American Journal of Physiology-Cell Physiology is dedicated to innovative approaches to the study of cell and molecular physiology. Contributions that use cellular and molecular approaches to shed light on mechanisms of physiological control at higher levels of organization also appear regularly. Manuscripts dealing with the structure and function of cell membranes, contractile systems, cellular organelles, and membrane channels, transporters, and pumps are encouraged. Studies dealing with integrated regulation of cellular function, including mechanisms of signal transduction, development, gene expression, cell-to-cell interactions, and the cell physiology of pathophysiological states, are also eagerly sought. Interdisciplinary studies that apply the approaches of biochemistry, biophysics, molecular biology, morphology, and immunology to the determination of new principles in cell physiology are especially welcome.