Prenatal exposure to di(isononyl) cyclohexane-1,2-dicarboxylate and adverse birth outcomes in the USA: a prospective analysis of births in a large American birth cohort

IF 10.2 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2026-10-04 DOI:10.1016/j.envint.2026.110548

Leonardo Trasande, Morgan E. Nelson, Akram Alshawabkeh, Emily S. Barrett, Jessie P. Buckley, Dana Dabelea, Anne L. Dunlop, Julie B. Herbstman, John D. Meeker, Mrudula Naidu, Craig Newschaffer, Amy M. Padula, Megan E. Romano, Douglas M. Ruden, Sheela Sathyanarayana, Susan L. Schantz, Anne P. Starling, Taylor M. Etzel, for the ECHO Cohort Consortium

引用次数: 0

Abstract

A large body of evidence has documented the effects of ortho-phthalates, additives to soft plastic used in food packaging, on premature birth. Ortho-phthalates are increasingly replaced with alternatives including tere-phthalates and di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH). A limited toxicological literature suggests that DINCH metabolites disrupt sex hormones and promote oxidant stress known to contribute to adverse birth outcomes, and epidemiologic studies have also been limited in sample size, inclusivity of different populations and measurements at different time points in pregnancy.

查看原文本刊更多论文

产前暴露于二（异ononyl）环己烷-1,2-二羧酸酯和不良出生结局在美国：在一个大型美国出生队列出生的前瞻性分析

大量证据证明，食品包装中使用的软塑料添加剂邻苯二甲酸酯对早产的影响。邻苯二甲酸酯越来越多地被邻苯二甲酸酯和二（异壬基）环己烷-1,2-二羧酸酯（DINCH）等替代品所取代。有限的毒理学文献表明，DINCH代谢物会破坏性激素并促进氧化应激，从而导致不良的出生结局，流行病学研究在样本量、不同人群的包容性和怀孕不同时间点的测量方面也受到限制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.