Association Between Anterior Laryngeal Microweb and Vocal Fold Nodules: A Case-Control Study.

IF 2.3 4区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Journal of Voice Pub Date : 2026-10-02 DOI:10.1016/j.jvoice.2026.09.017

Claudia Esper Zamar, Sergio A Terrasa, Jorgelina Pachamé, Iris Rodríguez, Federico Sala

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引用次数: 0

Abstract

Objectives: This study aimed to determine whether congenital anterior laryngeal microweb is associated with vocal fold nodules (VFN), and to assess its prevalence in patients diagnosed with VFN and the coexistence of multiple minor structural alterations of the vocal cords (MSAs) as described by Paulo Pontes.

Methods: A retrospective case-control study was conducted in patients evaluated between 2012 and 2024. A total of 99 patients with VFN were included in the case group. A total of 649 were included in the control group, described as patients without VFN. Odds ratios (OR) and 95% confidence intervals (CI) were calculated.

Results: The prevalence of microweb was 16% (16/99) in cases and 5% (36/649) in controls. After adjusting for sex, age at diagnosis, smoking status, coexistence of other minor laryngeal alterations, asthma, rhinitis, gastroesophageal reflux, and professional voice use, an association was observed (OR 4.14; 95% CI 1.82-9.39) between a history of laryngeal microweb and the development of VFN. Among the 96 patients with MSAs, 11 (11%) presented more than one alteration.

Conclusion: This is the first study to attempt to control for potential confounding through a case-control design, confirming the association between anterior laryngeal microweb and VFN.

Level of evidence: 3:

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喉前微网与声带结节的关系：一项病例对照研究。

目的：本研究旨在确定先天性喉前微网是否与声带结节（VFN）有关，并评估其在诊断为VFN的患者中的患病率，以及Paulo Pontes所描述的多重声带轻微结构改变（MSAs）的共存。方法：采用回顾性病例对照研究，选取2012 - 2024年间评估的患者。病例组共纳入99例VFN患者。对照组为无VFN患者，共649例。计算优势比（OR）和95%置信区间（CI）。结果：病例微网患病率为16%(16/99)，对照组为5%（36/649）。在调整性别、诊断年龄、吸烟状况、其他轻微喉部病变的共存、哮喘、鼻炎、胃食管反流和专业语音使用等因素后，观察到喉微网病史与VFN的发展之间存在关联（OR 4.14; 95% CI 1.82-9.39）。在96例msa患者中，11例（11%）出现不止一种改变。结论：这是第一个试图通过病例对照设计来控制潜在混淆的研究，证实了喉前微网和VFN之间的关联。证据等级：3；

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Voice 医学-耳鼻喉科学

CiteScore

4.00

自引率

13.60%

发文量

395

审稿时长

59 days

期刊介绍： The Journal of Voice is widely regarded as the world''s premiere journal for voice medicine and research. This peer-reviewed publication is listed in Index Medicus and is indexed by the Institute for Scientific Information. The journal contains articles written by experts throughout the world on all topics in voice sciences, voice medicine and surgery, and speech-language pathologists'' management of voice-related problems. The journal includes clinical articles, clinical research, and laboratory research. Members of the Foundation receive the journal as a benefit of membership.