{"title":"Cognitive outcomes following neurosurgery for frontal intracerebral tumors: A systematic review and meta-analysis.","authors":"Elisa Pellencin, Fabio Masina, Nicolò Castelli, Giovanni Carone, Alexa Schincariol, Cristina Scarpazza, Alessandro Perin, Konstantinos Priftis","doi":"10.1017/S135561772610215X","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Neurosurgical resection of frontal lobe tumors poses specific challenges to the patients. Even when lesions involve the so-called \"non-eloquent\" areas, such as the prefrontal cortex, neurosurgery can still affect critical functions, because the prefrontal regions are essential for executive functions and other complex cognitive processes. The aim of this study is to systematically review the literature and quantitatively assess the impact of frontal lobe tumor resection on patients' cognitive functioning.</p><p><strong>Methods: </strong>In the present systematic review and meta-analysis, we synthesized data from 50 studies that included pre- and post-neurosurgery neuropsychological assessments. In addition, we conducted a meta-analysis of a subset of studies (<i>n</i> = 15) including sufficient data to quantitatively evaluate the cognitive effects of frontal lobe tumor resections.</p><p><strong>Results: </strong>We found that cognitive performance, after neurosurgery, was not significantly changed compared to pre-neurosurgery performance. We also identified several limitations in the literature, including variability in neuropsychological assessment protocols, differences in follow-up time points, inconsistent reporting of baseline cognitive functioning, and underpowered sample sizes.</p><p><strong>Conclusions: </strong>In future studies, researchers should adopt standardized, comprehensive assessments, with well-powered cohorts and long-term follow-ups, to better characterize post-neurosurgical cognitive outcomes, including those regarding \"non-eloquent\" frontal regions. A multidisciplinary and harmonized approach remains crucial for understanding the cognitive impact of frontal lobe tumor neurosurgery and for improving patient care.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"1-17"},"PeriodicalIF":3.0000,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the International Neuropsychological Society","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1017/S135561772610215X","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Neurosurgical resection of frontal lobe tumors poses specific challenges to the patients. Even when lesions involve the so-called "non-eloquent" areas, such as the prefrontal cortex, neurosurgery can still affect critical functions, because the prefrontal regions are essential for executive functions and other complex cognitive processes. The aim of this study is to systematically review the literature and quantitatively assess the impact of frontal lobe tumor resection on patients' cognitive functioning.
Methods: In the present systematic review and meta-analysis, we synthesized data from 50 studies that included pre- and post-neurosurgery neuropsychological assessments. In addition, we conducted a meta-analysis of a subset of studies (n = 15) including sufficient data to quantitatively evaluate the cognitive effects of frontal lobe tumor resections.
Results: We found that cognitive performance, after neurosurgery, was not significantly changed compared to pre-neurosurgery performance. We also identified several limitations in the literature, including variability in neuropsychological assessment protocols, differences in follow-up time points, inconsistent reporting of baseline cognitive functioning, and underpowered sample sizes.
Conclusions: In future studies, researchers should adopt standardized, comprehensive assessments, with well-powered cohorts and long-term follow-ups, to better characterize post-neurosurgical cognitive outcomes, including those regarding "non-eloquent" frontal regions. A multidisciplinary and harmonized approach remains crucial for understanding the cognitive impact of frontal lobe tumor neurosurgery and for improving patient care.
期刊介绍：
The Journal of the International Neuropsychological Society is the official journal of the International Neuropsychological Society, an organization of over 4,500 international members from a variety of disciplines. The Journal of the International Neuropsychological Society welcomes original, creative, high quality research papers covering all areas of neuropsychology. The focus of articles may be primarily experimental, applied, or clinical. Contributions will broadly reflect the interest of all areas of neuropsychology, including but not limited to: development of cognitive processes, brain-behavior relationships, adult and pediatric neuropsychology, neurobehavioral syndromes (such as aphasia or apraxia), and the interfaces of neuropsychology with related areas such as behavioral neurology, neuropsychiatry, genetics, and cognitive neuroscience. Papers that utilize behavioral, neuroimaging, and electrophysiological measures are appropriate.
To assure maximum flexibility and to promote diverse mechanisms of scholarly communication, the following formats are available in addition to a Regular Research Article: Brief Communication is a shorter research article; Rapid Communication is intended for "fast breaking" new work that does not yet justify a full length article and is placed on a fast review track; Case Report is a theoretically important and unique case study; Critical Review and Short Review are thoughtful considerations of topics of importance to neuropsychology and include meta-analyses; Dialogue provides a forum for publishing two distinct positions on controversial issues in a point-counterpoint format; Special Issue and Special Section consist of several articles linked thematically; Letter to the Editor responds to recent articles published in the Journal of the International Neuropsychological Society; and Book Review, which is considered but is no longer solicited.
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