Axial Length-Adjusted Normative Reference Values for Retinal Layer Thickness in a Population-Based OCT Study.

IF 2.7 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2026-10-05 DOI:10.1167/tvst.15.10.5

Mi Yeon Song, Min Seong Kim, Mingui Kong

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引用次数: 0

Abstract

Purpose: To establish axial length-adjusted normative reference values for retinal layer thickness using population-based optical coherence tomography (OCT) data and evaluate their clinical implications in highly myopic eyes.

Methods: This cross-sectional study used Korea National Health and Nutrition Examination Survey 2017-2021 data. Participants aged ≥19 years with reliable OCT and axial length measurements and without major ophthalmic disease were included. Sampling-weighted quantile regression adjusted for age and sex estimated axial length-specific percentiles for peripapillary retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), and outer retinal thickness, with cluster-bootstrap 95% confidence intervals respecting the survey design. Reference values covered the data-supported range (22-28 mm). RNFL abnormality was reclassified in highly myopic eyes (axial length ≥26.5 mm; sensitivity analysis, ≥26.0 mm).

Results: Overall, 10,062 participants were included. Between axial lengths of 22 and 27 mm, median RNFL thickness decreased significantly by 12.4 µm (13.1%; 95% confidence interval [CI], 10.9-13.5; P < 0.001) and GCIPL by 8.2 µm (10.1%; 95% CI, 7.2-9.3; P < 0.001), whereas outer retinal thickness decreased by only 3.2 µm (2.5%). Among 402 highly myopic eyes, the proportion with abnormal average RNFL thickness fell from 16.7% to 4.0% after axial length adjustment (51 of 67 abnormal eyes reclassified as normal), whereas the temporal quadrant showed the opposite pattern.

Conclusions: Retinal layer thickness varies substantially according to axial length, particularly in inner retinal layers. Axial length-adjusted normative references may improve OCT interpretation in highly myopic eyes.

Translational relevance: Incorporating axial length into OCT normative interpretation may improve clinical assessment of retinal thickness in increasingly myopic populations.

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以人群为基础的OCT研究中视轴长度调整视网膜层厚度的标准参考值。

目的：利用基于人群的光学相干断层扫描（OCT）数据建立视轴长度调整视网膜层厚度的标准参考值，并评价其在高度近视眼中的临床意义。方法：本横断面研究使用了韩国国家健康与营养调查2017-2021年的数据。参与者年龄≥19岁，具有可靠的OCT和眼轴长度测量，且无重大眼科疾病。对年龄和性别进行抽样加权分位数回归，估计乳头周围视网膜神经纤维层（RNFL）、神经节细胞-内丛状层（GCIPL）和视网膜外层厚度的轴向长度特异性百分位数，聚类自助95%置信区间尊重调查设计。参考值涵盖数据支持的范围（22- 28mm）。高度近视眼（眼轴长度≥26.5 mm；敏感性分析≥26.0 mm）重新分类RNFL异常。结果：总共纳入了10062名参与者。在轴向长度为22和27 mm之间，中位RNFL厚度显著下降12.4µm(13.1%； 95%可信区间[CI]， 10.9-13.5; P < 0.001)， GCIPL厚度显著下降8.2µm (10.1%; 95% CI, 7.2-9.3; P < 0.001)，而视网膜外层厚度仅下降3.2µm（2.5%）。在402只高度近视眼中，经轴长调整后，RNFL平均厚度异常的比例从16.7%下降到4.0%（67只异常眼中有51只恢复正常），而颞象限则相反。结论：视网膜层厚度随轴向长度变化很大，尤其是视网膜内层。视轴长度调整后的标准参考文献可改善高度近视眼的OCT判读。翻译相关性：在日益近视的人群中，将眼轴长度纳入OCT规范解释可能会改善视网膜厚度的临床评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.