{"title":"Leukocytosis in acute stroke: A prospective study from an emergency department setting.","authors":"Muhammad Abas Khan","doi":"10.12669/pjms.42.9.14805","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To determine the total leukocyte count (TLC) in patients with acute stroke and assess its association with stroke type and age.</p><p><strong>Methodology: </strong>This prospective observational study was conducted at the Department of Emergency Medicine, Lady Reading Hospital, Peshawar, from May to November 2025. Adult patients with acute ischemic or hemorrhagic stroke were enrolled by non-probability consecutive sampling. TLC was measured at presentation, and age and stroke subtype were recorded. Patients with active infections, inflammatory diseases, hematological disorders, or immunosuppressive therapy were excluded. Data were analyzed using SPSS version 23. A one sample <i>t-test</i> was applied to compare the mean TLC value of the study population with the international reference mean TLC value of 7×10<sup>9</sup>/L. Chi-square assessed the association between TLC category and stroke type. One-way ANOVA compared TLC across age groups (30-49, 50-69, ≥70 years), and Pearson correlation assessed the relationship between age and TLC. A p-value <0.05 was considered significant.</p><p><strong>Results: </strong>Ninety patients were included. Mean TLC was significantly higher than the reference value (11.95±4.62×10<sup>9</sup>/L; p<0.001). No significant association was found between TLC category and stroke type (p=0.399). TLC did not differ significantly across age groups (p=0.119), and no significant correlation was observed between age and TLC (r=-0.108; p=0.313).</p><p><strong>Conclusion: </strong>TLC was elevated in acute stroke but showed no significant association with stroke subtype or age. Although leukocytosis is common in acute stroke, TLC alone has limited value in differentiating stroke types. Larger studies are needed to evaluate its prognostic significance.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 9","pages":"2284-2288"},"PeriodicalIF":1.6000,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624430/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Journal of Medical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12669/pjms.42.9.14805","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: To determine the total leukocyte count (TLC) in patients with acute stroke and assess its association with stroke type and age.
Methodology: This prospective observational study was conducted at the Department of Emergency Medicine, Lady Reading Hospital, Peshawar, from May to November 2025. Adult patients with acute ischemic or hemorrhagic stroke were enrolled by non-probability consecutive sampling. TLC was measured at presentation, and age and stroke subtype were recorded. Patients with active infections, inflammatory diseases, hematological disorders, or immunosuppressive therapy were excluded. Data were analyzed using SPSS version 23. A one sample t-test was applied to compare the mean TLC value of the study population with the international reference mean TLC value of 7×109/L. Chi-square assessed the association between TLC category and stroke type. One-way ANOVA compared TLC across age groups (30-49, 50-69, ≥70 years), and Pearson correlation assessed the relationship between age and TLC. A p-value <0.05 was considered significant.
Results: Ninety patients were included. Mean TLC was significantly higher than the reference value (11.95±4.62×109/L; p<0.001). No significant association was found between TLC category and stroke type (p=0.399). TLC did not differ significantly across age groups (p=0.119), and no significant correlation was observed between age and TLC (r=-0.108; p=0.313).
Conclusion: TLC was elevated in acute stroke but showed no significant association with stroke subtype or age. Although leukocytosis is common in acute stroke, TLC alone has limited value in differentiating stroke types. Larger studies are needed to evaluate its prognostic significance.
目的：测定急性脑卒中患者的总白细胞计数（TLC），并评价其与脑卒中类型和年龄的关系。方法：这项前瞻性观察性研究于2025年5月至11月在白沙瓦雷丁夫人医院急诊科进行。采用非概率连续抽样方法对急性缺血性或出血性脑卒中成年患者进行研究。患者就诊时进行薄层色谱测定，并记录年龄和脑卒中亚型。排除有活动性感染、炎症性疾病、血液系统疾病或免疫抑制治疗的患者。数据分析采用SPSS version 23。采用单样本t检验将研究人群的平均TLC值与国际参考平均TLC值7×109/L进行比较。卡方评估TLC分类与脑卒中类型之间的关系。单因素方差分析比较各年龄组（30-49岁、50-69岁、≥70岁）的TLC， Pearson相关性评估年龄与TLC之间的关系。p值结果：纳入90例患者。结论：急性脑卒中患者TLC升高，但与脑卒中亚型、年龄无显著相关性。虽然白细胞增多在急性脑卒中中很常见，但单独的TLC在区分脑卒中类型方面价值有限。需要更大规模的研究来评估其预后意义。
期刊介绍：
It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad.
Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.
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