Daniel Lobato Ferreira Ferraz, Brenda Corrêa Santos, Ana Carolina Evangelista Colafêmina, Ivan José Correia-Neto, Alan Roger Santos-Silva, Marcio Ajudarte Lopes
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引用次数: 0
Abstract
Objective: Proliferative verrucous leukoplakia is an oral potentially malignant disorder with a difficult diagnosis. A band-like chronic inflammatory infiltrate is frequently described in early lesions, but its prevalence and prognostic relevance remain unclear. This study aimed to estimate the prevalence of this feature in proliferative verrucous leukoplakia and assess its prognostic value.
Methods: A systematic review and meta-analysis were conducted according to PRISMA guidelines, with protocol registration in PROSPERO (CRD420251249570). Electronic databases and gray literature were searched. Observational studies reporting a band-like chronic inflammatory infiltrate in lesions from patients with proliferative verrucous leukoplakia were included. Data extraction and risk of bias assessment were performed independently. Random effects models estimated pooled prevalence and odds ratios for malignant transformation.
Results: Eleven studies including 307 patients were analyzed. The pooled prevalence of a band-like chronic inflammatory infiltrate was 57%. Malignant transformation occurred in 39.5% of cases with this feature and 53% of cases without it. Meta-analysis revealed no statistically significant association between a band-like chronic inflammatory infiltrate and malignant transformation.
Conclusions: Band-like chronic inflammatory infiltrates are common in proliferative verrucous leukoplakia, but current evidence is insufficient to determine whether this feature is associated with malignant transformation and clinically meaningful effects cannot be excluded.
期刊介绍：
Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.
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