{"title":"Diagnostic Value of ANA Titer, Anti-ds-DNA, Anti-nRNPSm, and Sm Antibodies in Early Atypical Systemic Lupus Erythematosus.","authors":"Jianqiao Zhang, Meichen Liu, Qing Liu, Dong Chen, Meng Zhang","doi":"10.12669/pjms.42.9.14966","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the diagnostic value of antinuclear antibody(ANA) titer, anti-double-stranded DNA(anti-ds-DNA) antibody, anti-nuclear ribonucleoprotein/Smith(anti-nRNPSm) antibody, and Smith (Sm) antibody for early atypical systemic lupus erythematosus(SLE).</p><p><strong>Methodology: </strong>This was a retrospective study. Forty-nine patients diagnosed with early atypical SLE admitted to Affiliated Hospital of Hebei University between January 2023 to June 2025 were assigned to Group-A, and 66 patients with other autoimmune diseases admitted during the same period were enrolled in Group-B. Compared the results of ANA, anti-ds-DNA, anti-nRNPSm and Sm antibody tests between the two groups, and analyzed the diagnostic value of the individual indicators and their combined detection for early atypical SLE.</p><p><strong>Results: </strong>There were statistically significant differences in the results of ANA, anti-ds-DNA, anti-nRNPSm and Sm antibodies between the two groups(P<0.05). Multivariate Logistic regression analysis confirmed that ANA, anti-ds-DNA, anti-nRNPSm and Sm were independent influencing factors for early atypical SLE (<i>P</i><0.05). ROC curve analysis showed that the AUC of combined diagnosis was 0.856, with a predictive sensitivity of 87.8%, a specificity of 71.2%, and a predictive probability of 0.79. Significant differences in AUC were observed between ANA and anti-ds-DNA antibody, Sm antibody, or the four-antibody combination(<i>P</i><0.05); between anti-ds-DNA antibody and the four-antibody combination(<i>P</i><0.05); and between anti-nRNPSm antibody, Sm antibody and the four-antibody combination(<i>P</i><0.05).</p><p><strong>Conclusion: </strong>ANA, anti-ds-DNA, anti-nRNPSm and Sm antibodies are major independent influencing factors for early atypical SLE. Combined detection of these indicators may effectively improve the diagnostic value for this disease.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 9","pages":"2318-2323"},"PeriodicalIF":1.6000,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624448/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Journal of Medical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12669/pjms.42.9.14966","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To explore the diagnostic value of antinuclear antibody(ANA) titer, anti-double-stranded DNA(anti-ds-DNA) antibody, anti-nuclear ribonucleoprotein/Smith(anti-nRNPSm) antibody, and Smith (Sm) antibody for early atypical systemic lupus erythematosus(SLE).
Methodology: This was a retrospective study. Forty-nine patients diagnosed with early atypical SLE admitted to Affiliated Hospital of Hebei University between January 2023 to June 2025 were assigned to Group-A, and 66 patients with other autoimmune diseases admitted during the same period were enrolled in Group-B. Compared the results of ANA, anti-ds-DNA, anti-nRNPSm and Sm antibody tests between the two groups, and analyzed the diagnostic value of the individual indicators and their combined detection for early atypical SLE.
Results: There were statistically significant differences in the results of ANA, anti-ds-DNA, anti-nRNPSm and Sm antibodies between the two groups(P<0.05). Multivariate Logistic regression analysis confirmed that ANA, anti-ds-DNA, anti-nRNPSm and Sm were independent influencing factors for early atypical SLE (P<0.05). ROC curve analysis showed that the AUC of combined diagnosis was 0.856, with a predictive sensitivity of 87.8%, a specificity of 71.2%, and a predictive probability of 0.79. Significant differences in AUC were observed between ANA and anti-ds-DNA antibody, Sm antibody, or the four-antibody combination(P<0.05); between anti-ds-DNA antibody and the four-antibody combination(P<0.05); and between anti-nRNPSm antibody, Sm antibody and the four-antibody combination(P<0.05).
Conclusion: ANA, anti-ds-DNA, anti-nRNPSm and Sm antibodies are major independent influencing factors for early atypical SLE. Combined detection of these indicators may effectively improve the diagnostic value for this disease.
期刊介绍：
It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad.
Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.
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