Immunotherapy and concomitant antibiotic treatment: A cautionary case report of a potential oral adverse event.

IF 4.4 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of the American Dental Association Pub Date : 2026-09-30 DOI:10.1016/j.adaj.2026.06.012

Quinton Steere, Sonal S Shah

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引用次数: 0

Abstract

Background: Erythematous oral lesions have a broad differential diagnosis, including trauma, vascular lesions, precancer and cancer, and opportunistic infections. The authors present a case of erythematous palatal lesions in a male patient undergoing concurrent immunotherapy and antibiotic therapy.

Case description: A 38-year-old man with ankylosing spondylitis undergoing long-term adalimumab (Humira; AbbVie) therapy sought treatment for asymptomatic erythematous palatal lesions after amoxicillin use. Clinical examination revealed multiple well-defined flat red lesions involving the hard and soft palate. Although the manifestation was atypical, a clinical diagnosis of erythematous candidiasis was made. Nystatin mouthrinse was prescribed and resulted in complete resolution of the lesions, supporting the clinical diagnosis. No recurrence was observed at 6-month follow-up.

Practical implications: With immunotherapy use becoming more common, dental care professionals should recognize the increased risk of developing opportunistic infections that may manifest atypically in these patients. A thorough medical history is essential.

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免疫治疗和联合抗生素治疗：一个潜在的口服不良事件的警示病例报告。

背景：口腔红斑性病变具有广泛的鉴别诊断，包括创伤、血管病变、癌前病变和癌前病变以及机会性感染。作者提出一个病例的红斑性腭病变的男性患者接受同时免疫治疗和抗生素治疗。病例描述：一名患有强直性脊柱炎的38岁男性，长期接受阿达木单抗（Humira; AbbVie）治疗，在使用阿莫西林后寻求治疗无症状的腭红斑性病灶。临床检查发现多个明确的扁平红色病变，包括软硬腭。虽然表现不典型，但临床诊断为红斑性念珠菌病。处方制霉菌素漱口剂并导致病变完全消退，支持临床诊断。随访6个月无复发。实际意义：随着免疫疗法的使用越来越普遍，牙科保健专业人员应该认识到这些患者出现非典型机会性感染的风险增加。详细的病史是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Dental Association 医学-牙科与口腔外科

CiteScore

5.30

自引率

10.30%

发文量

221

审稿时长

34 days

期刊介绍： There is not a single source or solution to help dentists in their quest for lifelong learning, improving dental practice, and dental well-being. JADA+, along with The Journal of the American Dental Association, is striving to do just that, bringing together practical content covering dentistry topics and procedures to help dentists—both general dentists and specialists—provide better patient care and improve oral health and well-being. This is a work in progress; as we add more content, covering more topics of interest, it will continue to expand, becoming an ever-more essential source of oral health knowledge.