Efficacy and safety of medical expulsive therapy (MET) after extracorporeal shockwaves lithotripsy (SWL) in pediatric patients.

IF 2.2 3区医学 Q2 PEDIATRICS

Journal of Pediatric Urology Pub Date : 2026-09-17 DOI:10.1016/j.jpurol.2026.106288

Ahmed Bakr Eldesouky Hassan, Khaled Zaki Sheir, Ahmed Mohamed Elshal, Mahmoud Anees Bazeed, Ahmed Refat El-Nahas

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引用次数: 0

Abstract

Purpose: To evaluate the impact of tamsulosin as a post-SWL adjunctive treatment for pediatric urolithiasis.

Patients and methods: A randomized controlled trial (RCT) was carried out for children with renal stones amenable for SWL. Eligible children were randomized into 2 groups. Group 1 received tamsulosin (0.01 mg/kg once daily) for 2 weeks after each SWL session while group 2 served as a control. Stone clearance was defined as no residual fragments by low-dose non-contrast computed tomography (NCCT) at one and three months after last session.

Results: A total of 106 patients were included (53 in each group). Pre-SWL patients and stone criteria were comparable between both groups. Stone clearance was achieved in 43 patients (81.1%) in group 1 and 36 patients (67.9%) in group 2 (P = 0.119). Time to stone clearance was comparable for both groups (P = 0.110). Post-SWL complications were encountered in one patient (1.9%) in group 1 and three patients (5.7%) in group 2 (P = 0.308). Tamsulosin minor adverse effects were observed in 18.9%, but no patients discontinue treatment.

Conclusions: Tamsulosin treatment following SWL for renal stones in children showed trends for increasing SFR and decreasing complications in comparison with control group. However, statistically significant differences were not achieved.

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小儿体外冲击波碎石术（SWL）后医学排气治疗（MET）的有效性和安全性。

目的：评价坦索罗辛作为swl后辅助治疗小儿尿石症的影响。患者和方法：对适合SWL治疗的肾结石患儿进行随机对照试验（RCT）。将符合条件的儿童随机分为两组。组1在每次SWL后给予坦索罗辛（0.01 mg/kg，每日1次），持续2周；组2作为对照组。结石清除定义为在最后一次治疗后1个月和3个月通过低剂量非对比计算机断层扫描（NCCT）无残留碎片。结果：共纳入106例患者，每组53例。两组间swl前患者和结石标准具有可比性。1组有43例（81.1%）患者结石清除，2组有36例（67.9%）患者结石清除（P = 0.119）。两组的结石清除时间具有可比性（P = 0.110）。组1出现swl术后并发症1例（1.9%），组2出现3例（5.7%）（P = 0.308）。18.9%的患者有坦索罗辛轻微不良反应，但没有患者停止治疗。结论：与对照组相比，坦索罗辛治疗儿童肾结石SWL后SFR升高，并发症减少。然而，没有统计学上的显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatric Urology PEDIATRICS-UROLOGY & NEPHROLOGY

CiteScore

3.70

自引率

15.00%

发文量

330

审稿时长

4-8 weeks

期刊介绍： The Journal of Pediatric Urology publishes submitted research and clinical articles relating to Pediatric Urology which have been accepted after adequate peer review. It publishes regular articles that have been submitted after invitation, that cover the curriculum of Pediatric Urology, and enable trainee surgeons to attain theoretical competence of the sub-specialty. It publishes regular reviews of pediatric urological articles appearing in other journals. It publishes invited review articles by recognised experts on modern or controversial aspects of the sub-specialty. It enables any affiliated society to advertise society events or information in the journal without charge and will publish abstracts of papers to be read at society meetings.