Theta-frequency subthalamic nucleus deep brain stimulation selectively improves visual attention in Parkinson's disease.

IF 5.2 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2026-09-18 eCollection Date: 2026-01-01 DOI:10.3389/fnagi.2026.1961905

Yue Lu, Quan Zhang, Hutao Xie, Houyou Fan, Yichen Xu, Guofan Qin, Yutong Zhuang, Jiansong Huang, Anchao Yang, Yin Jiang, Jianguo Zhang

{"title":"Theta-frequency subthalamic nucleus deep brain stimulation selectively improves visual attention in Parkinson's disease.","authors":"Yue Lu, Quan Zhang, Hutao Xie, Houyou Fan, Yichen Xu, Guofan Qin, Yutong Zhuang, Jiansong Huang, Anchao Yang, Yin Jiang, Jianguo Zhang","doi":"10.3389/fnagi.2026.1961905","DOIUrl":null,"url":null,"abstract":"Objective: Visual attention deficits are common but under-recognized in Parkinson's disease (PD), and we investigate whether theta-frequency (5 Hz) STN-DBS differentially modulates visual attention compared with high-frequency (130 Hz) stimulation in PD patients.Methods: Thirty-nine PD patients with bilateral STN-DBS perform an attentional capture task under three stimulation conditions (OFF, low-frequency, high-frequency). Patients are stratified into impaired (n = 21) and normal (n = 18) visual attention groups based on their accuracy in the AC-distractor task during OFF-stimulation, with <90% accuracy defining impairment. Behavioral accuracy and reaction time are analyzed using Bayesian mixed-effects models. P300 amplitudes and latencies are measured using electroencephalography.Results: In the impaired group, 5 Hz stimulation significantly improves accuracy in the distractor condition compared with OFF (BF > 1,000), whereas 130 Hz stimulation reduces accuracy (BF = 122.8). This behavioral pattern is paralleled by enhanced P300 amplitude and prolonged latency under 5 Hz stimulation, and suppressed P300 amplitude under 130 Hz stimulation. No significant stimulation effects are observed in the normal group.Conclusion: Theta-frequency STN-DBS selectively improves visual attention in PD with pre-existing attentional deficits, likely by enhancing top-down attentional resource allocation, while high-frequency stimulation impairs performance.","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"18 ","pages":"1961905"},"PeriodicalIF":5.2000,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630993/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Aging Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnagi.2026.1961905","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Visual attention deficits are common but under-recognized in Parkinson's disease (PD), and we investigate whether theta-frequency (5 Hz) STN-DBS differentially modulates visual attention compared with high-frequency (130 Hz) stimulation in PD patients.

Methods: Thirty-nine PD patients with bilateral STN-DBS perform an attentional capture task under three stimulation conditions (OFF, low-frequency, high-frequency). Patients are stratified into impaired (n = 21) and normal (n = 18) visual attention groups based on their accuracy in the AC-distractor task during OFF-stimulation, with <90% accuracy defining impairment. Behavioral accuracy and reaction time are analyzed using Bayesian mixed-effects models. P300 amplitudes and latencies are measured using electroencephalography.

Results: In the impaired group, 5 Hz stimulation significantly improves accuracy in the distractor condition compared with OFF (BF > 1,000), whereas 130 Hz stimulation reduces accuracy (BF = 122.8). This behavioral pattern is paralleled by enhanced P300 amplitude and prolonged latency under 5 Hz stimulation, and suppressed P300 amplitude under 130 Hz stimulation. No significant stimulation effects are observed in the normal group.

Conclusion: Theta-frequency STN-DBS selectively improves visual attention in PD with pre-existing attentional deficits, likely by enhancing top-down attentional resource allocation, while high-frequency stimulation impairs performance.

查看原文本刊更多论文

高频丘脑底核深部脑刺激选择性改善帕金森病的视觉注意力。

目的：视觉注意缺陷在帕金森病（PD）中很常见，但未得到充分认识，我们研究了PD患者的高频（130 Hz）刺激与高频（5 Hz）刺激相比，低频STN-DBS是否能调节视觉注意。方法：39例PD双侧STN-DBS患者在关闭、低频、高频三种刺激条件下执行注意捕获任务。患者分层为受损(n = 21)和正常(n = 18)视觉注意力组根据他们的准确性在OFF-stimulation AC-distractor任务,与结果:受损组5 赫兹刺激显著提高精度的错误选择条件与(BF > 1000),而130年 赫兹刺激减少精度(BF = 122.8)。这种行为模式与5 Hz刺激下P300振幅增强和潜伏期延长相一致，而在130 Hz刺激下P300振幅被抑制。正常组未见明显刺激作用。结论：高频STN-DBS可能通过增强自上而下的注意力资源分配而选择性地改善PD患者的视觉注意力，而高频刺激则会损害其表现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.