Modality-specific quantitative radiologic characterization of diffuse sclerosing osteomyelitis of the mandible: a pilot study.

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Investigations Pub Date : 2026-10-02 DOI:10.1007/s00784-026-07160-8

Katharina Theresa Obermeier, Wenko Smolka, Sven Otto, Anusha Abdullah, Gabriele Kaeppler, Eric Hesse, Ina Dewenter, Yoana Malenova

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引用次数: 0

Abstract

Objectives: Diffuse sclerosing osteomyelitis (DSO) of the mandible is a rare chronic inflammatory disease characterized by recurrent painful swelling and trismus. While advanced stages are known to show radiographically evident bone sclerosis, objective quantitative imaging criteria remain poorly defined. This study aimed to characterize modality-specific radiological features of DSO using intra-individual side-to-side comparison of bone density and cortical thickness.

Materials and methods: This single-center retrospective study included 22 patients treated for DSO between 2010 and 2021. Pre-treatment panoramic radiographs were available for all patients, CT datasets for 6 patients, and CBCT for 3 patients. Bone density was quantified using relative grayscale values in panoramic radiography, Hounsfield units (HU) in CT, and gray values in CBCT. Cortical thickness was measured on CT using standardized regions of interest, with contralateral-side comparison. Two blinded observers performed all measurements.

Results: Quantitative analysis demonstrated significantly higher bone density on the affected side in panoramic radiography and CT (panoramic: 46.0 ± 4.0% vs. 39.0 ± 3.6%, p < 0.001; CT: 1220.9 ± 215.8 HU vs. 1108.0 ± 163.9 HU, p = 0.01). In the three available CBCT datasets, descriptively higher gray values were observed on the affected side. CT analysis revealed significantly increased cortical thickness (5.63 ± 0.96 mm vs. 3.86 ± 0.75 mm, p = 0.04). A blurred inferior alveolar nerve canal was consistently observed on panoramic radiographs.

Conclusions: Quantitative side-to-side assessment provides an objective radiological description of DSO and may support imaging assessment when interpreted together with clinical and histopathological findings.

Clinical relevance: In this selected cohort, DSO-affected regions showed relative densification, cortical thickening in the available CT examinations, and blurring of the inferior alveolar nerve canal on panoramic radiographs.

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下颌骨弥漫性硬化性骨髓炎的模式特异性定量放射学特征：一项初步研究。

目的：下颌骨弥漫性硬化性骨髓炎（DSO）是一种罕见的慢性炎症性疾病，其特征是复发性疼痛肿胀和牙关紧闭。虽然已知晚期表现出明显的骨硬化，但客观定量成像标准仍然不明确。本研究旨在通过个体内骨密度和皮质厚度的侧对侧比较来表征DSO的模式特异性放射学特征。材料和方法：本单中心回顾性研究纳入了2010年至2021年间接受DSO治疗的22例患者。治疗前所有患者均有全景x线片，6例患者有CT数据集，3例患者有CBCT数据集。采用全景x线摄影的相对灰度值、CT的Hounsfield单位（HU）和CBCT的灰度值来量化骨密度。在CT上使用标准化感兴趣区域测量皮质厚度，并与对侧比较。两名盲法观察者进行了所有的测量。结果：定量分析显示，在全景x线片和CT上，患侧骨密度明显较高（全景：46.0±4.0% vs. 39.0±3.6%,p）。结论：定量侧对侧评估提供了DSO的客观影像学描述，并可与临床和组织病理学结果一起解释影像学评估。临床相关性：在这个选定的队列中，dso影响区域在现有的CT检查中表现为相对致密化，皮层增厚，在全景x线片上表现为下牙槽神经管模糊。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Oral Investigations 医学-牙科与口腔外科

CiteScore

6.30

自引率

5.90%

发文量

484

审稿时长

3 months

期刊介绍： The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.