Rethinking Common Diagnoses: Idiopathic Multicentric Castleman Disease Presenting as TAFRO Syndrome: A Case Report.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

Clinical Case Reports Pub Date : 2026-09-30 eCollection Date: 2026-10-01 DOI:10.1002/ccr3.73663

Divita Rohatgi, Annesha Chakraborty, Sourav Kumar, Anurag Rohatgi

引用次数: 0

Abstract

Idiopathic multicentric Castleman disease (TAFRO subtype) can mimic common differentials. High suspicion is required for chronic systemic symptoms and generalized lymphadenopathy. As fine-needle aspiration is often non-diagnostic, early excisional biopsy is important. Rituximab-based therapy represents a guideline-supported alternative when anti-IL-6 treatment is unavailable or not feasible.

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重新思考常见诊断：特发性多中心Castleman病表现为TAFRO综合征：1例报告。

特发性多中心Castleman病（TAFRO亚型）可以模拟共同的差异。慢性全身性症状和全身性淋巴结病需要高度怀疑。由于细针穿刺通常无法诊断，因此早期切除活检非常重要。当抗il -6治疗不可用或不可行时，基于利妥昔单抗的治疗是一种指南支持的替代方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Case Reports MEDICINE, GENERAL & INTERNAL-

自引率

14.30%

发文量

1268

审稿时长

13 weeks

期刊介绍： Clinical Case Reports is different from other case report journals. Our aim is to directly improve global health and increase clinical understanding using case reports to convey important best practice information. We welcome case reports from all areas of Medicine, Nursing, Dentistry, and Veterinary Science and may include: -Any clinical case or procedure which illustrates an important best practice teaching message -Any clinical case or procedure which illustrates the appropriate use of an important clinical guideline or systematic review. As well as: -The management of novel or very uncommon diseases -A common disease presenting in an uncommon way -An uncommon disease masquerading as something more common -Cases which expand understanding of disease pathogenesis -Cases where the teaching point is based on an error -Cases which allow us to re-think established medical lore -Unreported adverse effects of interventions (drug, procedural, or other).