{"title":"Colombiains A–C, Three New Alkaloids From the Soft Coral-Derived Fungus Cladosporium colombiae CSGL 10M10","authors":"Jing Xie, Bing-Bing Liu, Yang-Ying Zheng, Jun-Feng Huan, Xiao-Yu Tian, Xiu-Ping Lin, Hui-Mei Xie, Yuan-Yuan Cheng, Cui-Xian Zhang","doi":"10.1002/cbdv.71769","DOIUrl":null,"url":null,"abstract":"<p>Three new alkaloids, colombiains <b>A</b>–<b>C</b> (<b>1</b>–<b>3</b>), together with 8 known ones (<b>4</b>–<b>11</b>), were isolated from the soft coral-derived fungus <i>Cladosporium colombiae</i> CSGL 10M10. Their structures were elucidated by spectroscopic interpretation, electronic circular dichroism (ECD), and single-crystal X-ray crystallographic methods. Compounds <b>6</b> and <b>11</b> exhibited significant cardioprotective activity against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in H9c2 myocardial cell line at 10 µM. In addition, a preliminary network pharmacology analysis of compound <b>6</b> suggested that <i>β</i>-carboline alkaloids might exert protective effects through a multi-target, multi-pathway mode of action, providing a rationale for future mechanistic studies.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"23 10","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13626256/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry & Biodiversity","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbdv.71769","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Three new alkaloids, colombiains A–C (1–3), together with 8 known ones (4–11), were isolated from the soft coral-derived fungus Cladosporium colombiae CSGL 10M10. Their structures were elucidated by spectroscopic interpretation, electronic circular dichroism (ECD), and single-crystal X-ray crystallographic methods. Compounds 6 and 11 exhibited significant cardioprotective activity against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in H9c2 myocardial cell line at 10 µM. In addition, a preliminary network pharmacology analysis of compound 6 suggested that β-carboline alkaloids might exert protective effects through a multi-target, multi-pathway mode of action, providing a rationale for future mechanistic studies.
期刊介绍：
Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level.
Since 2017, Chemistry & Biodiversity is published in an online-only format.
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