Stress-Induced Changes in Contractile Activity of Rat Aorta and Pulmonary Artery.

IF 0.7 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2026-09-30 DOI:10.1007/s10517-026-06747-1

S V Gusakova, V S Gusakova, E A Lebedeva, M A Pshemyskiy, M Kilin, L N Maslov

引用次数: 0

Abstract

Immobilization stress (12 and 24 h) simulated in female Wistar rats reduced the amplitude of phenylephrine-induced contraction of isolated aortic and pulmonary artery rings. Acetylcholine-induced, endothelium-dependent vasorelaxation of the aorta and pulmonary artery increased after 12-h stress exposure. Therefore, stress modulates the functional state of these arteries without signs of endothelial injury.

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应激诱导大鼠主动脉和肺动脉收缩活动的变化。

雌性Wistar大鼠模拟固定应激（12和24 h）降低了苯肾上腺素诱导的离体主动脉和肺动脉环收缩幅度。应激暴露12小时后，乙酰胆碱诱导的内皮依赖性主动脉和肺动脉血管舒张增强。因此，应激调节这些动脉的功能状态，而没有内皮损伤的迹象。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.