S V Kozin, A A Kravtsov, A V Moiseev, A D Rubailo, S V Bobrovnik, E R Vasilevskaya, A I Trofimenko, O M Lyasota
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引用次数: 0
Abstract
The neuroprotective and neurotrophic properties of magnesium chelidonate and chelidonic acid at concentrations of 0.01 and 0.1 mM were studied. It was found that magnesium chelidonate and chelidonic acid significantly reduced cell death in primary rat cerebellar neuroglial cultures, both in a model of glutamate excitotoxicity and under conditions of oxygen-glucose deprivation. Both substances exerted a stimulatory effect on the neurotrophic processes in chicken embryo dorsal root ganglion cultures. The neuroprotective and neurotrophic effects of the tested compounds were more pronounced at a concentration of 0.01 mM. In our experiments, magnesium salt of chelidonic acid produced more potent neuroprotective and neurotrophic effects on the studied cultures than chelidonic acid.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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