Evaluation of Therapeutic and Biopharmaceutical Properties of a Biadhesive Dental Paste Based on a Complex Immunoglobulin Preparation.

IF 0.7 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2026-06-01 Epub Date: 2026-10-01 DOI:10.1007/s10517-026-06753-3

K E Petrulenko, L R Seifullaeva, V V Shulakov, O O Prosycheva, M S Podporin, V N Tsarev, N B Demina, L A Korol, A V Alyoshkin, V A Alyoshkin, M N Anurova

引用次数: 0

Abstract

A topical mucoadhesive dosage form was developed for the treatment of infectious oral cavity diseases, consisting of a paste based on a combination of a complex immunoglobulin preparation (CIP) and interferon alpha-2b. CIP within the final formulation demonstrated robust antimicrobial activity against key oral pathogens (Staphylococcus aureus, Streptococcus intermedius, and Fusobacterium nucleatum). An optimal composition was selected that exhibited optimal mucoadhesion and a mucosal retention time of at least 90 min. The final formulation produced no local irritant effects.

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基于复合免疫球蛋白制剂的双胶粘剂牙膏的治疗和生物制药性能评价。

开发了一种用于治疗感染性口腔疾病的局部黏液剂型，由基于复合免疫球蛋白制剂（CIP）和干扰素α -2b组合的膏状物组成。最终配方中的CIP对主要口腔病原体（金黄色葡萄球菌、中间链球菌和核梭杆菌）具有强大的抗菌活性。选择了一种最佳组合物，该组合物表现出最佳的粘膜粘附性和粘膜保留时间至少为90分钟。最后的配方没有产生局部刺激性作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.