V V Ivanova, O N Serebryakova, A D Dolbnya, R I Pleshko, F V Alyabyev, I V Milto
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引用次数: 0
Abstract
The contractile apparatus of left-ventricular cardiomyocytes from from 180-day-old rats that had been born one day preterm was studied using polarization microscopy and transmission electron microscopy. In cardiomyocytes from preterm rats, the myofibrils had non-uniform thickness: along with thinned and disintegrated areas of myofibrils, thickened myofibrils were detected. Myofibril lysis was predominantly focal and less frequently diffuse. Cardiomyocytes with subsegmental contractures were observed. Mitochondria with signs of destruction were detected in cardiomyocytes from premature rats, while numerous small mitochondria that did not form intermitochondrial junctions were found in the dilated intermyofibrillar spaces. Mitochondrial damage leads to structural and functional disturbances of the cardiomyocyte contractile apparatus.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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