Effect of iTBS and rTMS Combined with Robotic Rehabilitation on Ambulation and Lower Extremity Motor Function in Chronic SCI Patients.

IF 2.3 4区医学 Q1 REHABILITATION

American Journal of Physical Medicine & Rehabilitation Pub Date : 2026-10-07 DOI:10.1097/PHM.0000000000003167

Ayse Naz Kalem Ozgen, Gokhan Yardimci, Bilge Yilmaz

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引用次数: 0

Abstract

Objective: To investigate the effectiveness of intermittent theta-burst stimulation (iTBS) and repetitive transcranial magnetic stimulation (rTMS) combined with robotic rehabilitation on ambulation and lower-extremity motor function in patients with spinal cord injury (SCI).

Design: This study was a single center, single blind, randomized controlled trial. A total of 30 patients with chronic incomplete SCI were randomly assigned in a 1:1:1 ratio to one of three intervention groups: high-frequency rTMS, iTBS, or sham iTBS. All interventions were administered in combination with robotic rehabilitation. Assessments were performed at baseline, post-treatment, and 4-week follow-up.

Results: Significant between-group differences were observed at 4 weeks for LEMS, SCIM III, and 10 MWT. Median improvements were 4.0, 5.0, and 0.0 for LEMS (P=.017, q=.050); 3.0, 5.0, and 0.0 for SCIM III (P=.016, q=.050); and 6.6, 5.7, and 0.7 for 10 MWT (P=.005, q=.046) in the rTMS, iTBS, and sham groups, respectively. No significant differences were observed between the active protocols, and no intervention-related adverse events occurred.

Conclusions: Both rTMS and iTBS combined with robotic rehabilitation were associated with improvements in lower-extremity function, although differences versus sham varied across outcomes. No significant differences were observed between the two active protocols.

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iTBS和rTMS联合机器人康复对慢性脊髓损伤患者行走和下肢运动功能的影响。

目的：探讨间歇性脉冲刺激（iTBS）和重复经颅磁刺激（rTMS）联合机器人康复对脊髓损伤（SCI）患者行走和下肢运动功能的影响。设计：本研究为单中心、单盲、随机对照试验。共有30名慢性不完全性脊髓损伤患者按1:1:1的比例随机分配到三个干预组之一：高频rTMS、iTBS或假iTBS。所有干预措施均与机器人康复相结合。在基线、治疗后和4周随访时进行评估。结果：LEMS、SCIM III和10 MWT在4周时观察到组间显著差异。LEMS的中位改善分别为4.0、5.0和0.0 (P= 0.017, q= 0.050)；SCIM III为3.0、5.0和0.0 (P= 0.016, q= 0.050)；rTMS组、iTBS组和sham组10 MWT分别为6.6、5.7和0.7 （P= 0.005, q= 0.046）。两种治疗方案之间没有显著差异，也没有发生干预相关的不良事件。结论：rTMS和iTBS联合机器人康复均与下肢功能改善相关，尽管与假手术的差异在结果上有所不同。两种有效方案之间无显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Physical Medicine & Rehabilitation 医学-康复医学

CiteScore

4.60

自引率

6.70%

发文量

423

审稿时长

1 months

期刊介绍： American Journal of Physical Medicine & Rehabilitation focuses on the practice, research and educational aspects of physical medicine and rehabilitation. Monthly issues keep physiatrists up-to-date on the optimal functional restoration of patients with disabilities, physical treatment of neuromuscular impairments, the development of new rehabilitative technologies, and the use of electrodiagnostic studies. The Journal publishes cutting-edge basic and clinical research, clinical case reports and in-depth topical reviews of interest to rehabilitation professionals. Topics include prevention, diagnosis, treatment, and rehabilitation of musculoskeletal conditions, brain injury, spinal cord injury, cardiopulmonary disease, trauma, acute and chronic pain, amputation, prosthetics and orthotics, mobility, gait, and pediatrics as well as areas related to education and administration. Other important areas of interest include cancer rehabilitation, aging, and exercise. The Journal has recently published a series of articles on the topic of outcomes research. This well-established journal is the official scholarly publication of the Association of Academic Physiatrists (AAP).