Oscar Ruz, Carlos Brito-Pacheco, Marina Vidrascu, Dominique Chapelle, Miguel A. Fernández
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引用次数: 0
Abstract
The thin-walled nature of the atrial myocardium can lead to artificial stiffening when full 3D electromechanical models are discretized using standard finite elements. In this work, we propose an electromechanical model of the left atrium based on a 3D-shell formulation that overcomes these limitations. The model incorporates both passive and active components of atrial tissue mechanics, while atrioventricular interaction is described by the coupling with a 0D electromechanical model of the left ventricle. The proposed approach is assessed under physiological and pathological conditions and systematically compared with the standard full 3D formulation. The results demonstrate the superior robustness and computational efficiency of the proposed 3D-shell electromechanical model.
期刊介绍：
Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that
(1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury,
(2) identify and quantify mechanosensitive responses and their mechanisms,
(3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and
(4) report discoveries that advance therapeutic and diagnostic procedures.
Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.
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